Associations of Arsenic Metabolites, Methylation Capacity, and Skin Lesions Caused by Chronic Exposure to High Arsenic in Tube Well Water

doi:10.1002/tox.22209

	Associations of Arsenic Metabolites, Methylation Capacity, and Skin Lesions Caused by Chronic Exposure to High Arsenic in Tube Well Water
	Yang, Linsheng 1; Chai, Yuanqing 1,2; Yu, Jiangping 1; Wei, Binggan 1; Xia, Yajuan 3; Wu, Kegong 3; Gao, Jianwei 1; Guo, Zhiwei 3; Cui, Na 3
刊名	ENVIRONMENTAL TOXICOLOGY
	2017
卷号	32 期号:1 页码:28-36
关键词	drinking water arsenic arsenic metabolites methylation capacity skin lesions
ISSN号	1520-4081
DOI	10.1002/tox.22209
通讯作者	Wei, Binggan(weibg@igsnrr.ac.cn)
英文摘要	To investigate the interaction between skin lesion status and arsenic methylation profiles, the concentrations and proportions of arsenic metabolites in urine and arsenic methylation capacities of study subjects were determined. The results showed that the mean urinary concentrations of iAs (inorganic arsenic), MMA (monomethylarsonic acid), DMA (dimethylarsinic acid), and TAs (total arsenic) were 75.65, 68.78, 265.81, and 410.24 mu g/L, respectively, in the skin lesions subjects. The highest values were observed in the multiple skin lesions subjects. Higher %iAs and %MMA, and lower %DMA, PMI (primary methylation index), and SMI (secondary methylation index) were found in skin lesions subjects. The multiple skin lesions subjects had highest %iAs and %MMA, and lowest %DMA, PMI, and SMI. The prevalence of skin lesions strongly, positively correlated with arsenic levels in drinking water. The elder persons also had higher frequency of skin lesions compared with younger persons. It can be concluded that arsenic levels in drinking water significantly affected the prevalence of skin lesions. Male subjects usually had higher proportions of skin lesions when compared with female subjects. Moreover, it may be concluded that MMA was significantly related to single skin lesion, whereas DMA and iAs were associated with multiple skin lesions. It seemed that MMA had greater toxicity to hyperkeratosis, whereas DMA and iAs had higher toxicity to depigmentation or pigmentation. (C) 2015 Wiley Periodicals, Inc.
资助项目	State Key Program of National Natural Science of China[41230749]
WOS关键词	DRINKING-WATER ; NORTHERN CHINA ; INNER-MONGOLIA ; BANGLADESH ; RISK ; RESIDENTS ; TOXICITY ; INDIVIDUALS ; CONSUMPTION ; CAPABILITY
WOS研究方向	Environmental Sciences & Ecology ; Toxicology ; Water Resources
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000393797000003
资助机构	State Key Program of National Natural Science of China
内容类型	期刊论文
源URL	[http://ir.igsnrr.ac.cn/handle/311030/64887]
专题	中国科学院地理科学与资源研究所
通讯作者	Wei, Binggan
作者单位	1.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Key Lab Land Surface Pattern & Simulat, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Inner Mongolia Ctr Endem Dis Control & Res, Hohhot, Inner Mongolia, Peoples R China
推荐引用方式 GB/T 7714	Yang, Linsheng,Chai, Yuanqing,Yu, Jiangping,et al. Associations of Arsenic Metabolites, Methylation Capacity, and Skin Lesions Caused by Chronic Exposure to High Arsenic in Tube Well Water[J]. ENVIRONMENTAL TOXICOLOGY,2017,32(1):28-36.
APA	Yang, Linsheng.,Chai, Yuanqing.,Yu, Jiangping.,Wei, Binggan.,Xia, Yajuan.,...&Cui, Na.(2017).Associations of Arsenic Metabolites, Methylation Capacity, and Skin Lesions Caused by Chronic Exposure to High Arsenic in Tube Well Water.ENVIRONMENTAL TOXICOLOGY,32(1),28-36.
MLA	Yang, Linsheng,et al."Associations of Arsenic Metabolites, Methylation Capacity, and Skin Lesions Caused by Chronic Exposure to High Arsenic in Tube Well Water".ENVIRONMENTAL TOXICOLOGY 32.1(2017):28-36.