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期刊论文 [45]
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Inhibition of the deubiquitinating enzyme USP47 as a novel targeted therapy for hematologic malignancies expressing mutant EZH2
期刊论文
LEUKEMIA, 2022
作者:
Yang, Jing
;
Weisberg, Ellen L.
;
Qi, Shuang
;
Ni, Wei
;
Mei, Husheng
收藏
  |  
浏览/下载:76/0
  |  
提交时间:2022/02/14
5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 19
作者:
Wang, Shuni
;
Yang, Hong
;
Su, Mingbo
;
Lian, Fulin
;
Cong, Zhanqing
收藏
  |  
浏览/下载:80/0
  |  
提交时间:2021/11/04
NSD2
Methyltransferase
HTS
Multiple myeloma
5-Aminonaphthalene derivatives
Inhibitor
Synthesis and structure-activity relationship studies of LLY-507 analogues as SMYD2 inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 5
作者:
Zhang, Bin
;
Liao, Liping
;
Wu, Fan
;
Zhang, Fengcai
;
Sun, Zhongya
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/05/24
SMYD2 inhibitors
Thermal shift assay
Structure-activity relationships
Biological roles of LSD1 beyond its demethylase activity
期刊论文
CELLULAR AND MOLECULAR LIFE SCIENCES, 2020
作者:
Gu, Feiying
;
Lin, Yuxin
;
Wang, Zhun
;
Wu, Xiaoxin
;
Ye, Zhenyue
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/11/26
LSD1
Demethylase
Ubiquitylation
FBXW7
Non-catalytic
Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers
期刊论文
2019, 卷号: 33, 期号: 8, 页码: 9672-9684
作者:
Wang, Chao
;
Zhang, Bin
;
Ratliff, Anna C.
;
Arrington, Justine
;
Chen, Jingjuan
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/01/03
Mettl21e
Myostatin
non-histone methylation
muscle atrophy
VCP/p97
Design, synthesis and anti leukemia cells proliferation activities of pyrimidylaminoquinoline derivatives as DOT1L inhibitors
期刊论文
BIOORGANIC CHEMISTRY, 2018, 卷号: 80, 页码: 649-654
作者:
Zhang, Li
;
Chen, Yantao
;
Liu, Na
;
Li, Linjuan
;
Xiao, Senhao
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2019/01/08
Pyrimidylaminoquinoline
Nonnucleoside DOT1L inhibitors
Amino side chains
Mixed-linage leukemia
Histone lysine methyltransferase
Histone deacetylation, as opposed to promoter methylation, results in epigenetic BIM silencing and resistance to EGFR TKI in NSCLC
期刊论文
ONCOLOGY LETTERS, 2018, 卷号: 15, 期号: 1
作者:
Zhao, Mingchuan
;
Zhang, Yishi
;
Li, Jiayu
;
Li, Xuefei
;
Cheng, Ningning
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/05
epidermal growth factor receptor-tyrosine kinase inhibitors
non-small cell lung cancer
bcl-2-like protein 11
histone deacylation
methylation
The Epigenetics of Alzheimer's Disease: Factors and Therapeutic Implications.
期刊论文
Frontiers in genetics, 2018, 页码: 579
作者:
Liu Xiaolei
;
Jiao Bin
;
Shen Lu
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/02/25
Alzheimer’s
disease
(AD)
DNA
methylation
epigenetics
histone
modifications
and
chromatin
structure
non-coding
RNA
(ncRNA)
The Epigenetics of Alzheimer's Disease: Factors and Therapeutic Implications.
期刊论文
Frontiers in genetics, 2018, 页码: 579
作者:
Liu Xiaolei
;
Jiao Bin
;
Shen Lu
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/02/25
Alzheimer’s
disease
(AD)
DNA
methylation
epigenetics
histone
modifications
and
chromatin
structure
non-coding
RNA
(ncRNA)
The Epigenetics of Alzheimer’s Disease: Factors and Therapeutic Implications
期刊论文
Frontiers in Genetics, 2018, 卷号: Vol.9
作者:
Xiaolei Liu
;
Bin Jiao
;
Lu Shen
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/02/25
Alzheimer’s
disease
(AD)
epigenetics
non-coding
RNA
(ncRNA)
DNA
methylation
histone
modifications
and
chromatin
structure
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