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科研机构
上海药物研究所 [608]
内容类型
期刊论文 [608]
发表日期
2021 [608]
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共608条,第1-10条
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发表日期:2021
专题:上海药物研究所
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A general strategy to the intracellular sensing of glycosidases using AIE-based glycoclusters
期刊论文
CHEMICAL SCIENCE, 2021, 卷号: 13, 期号: 1, 页码: 247-256
作者:
Dong, Lei
;
Zhang, Min-Yu
;
Han, Hai-Hao
;
Zang, Yi
;
Chen, Guo-Rong
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/01/18
Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy
期刊论文
Journal of Nanobiotechnology, 2021, 卷号: 19, 期号: 1
作者:
Shi,Junyu
;
Zhang,Yi
;
Zhang,Xiaomeng
;
Chen,Ruiying
;
Wei,Jianxu
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2022/01/04
Resveratrol
Macrophage
Periodontitis
Liposome
Immune microenvironment
Local delivery
A simple and effective method for identification of Fraxini Cortex from different sources by multi-mode fingerprint combined with chemometrics
期刊论文
JOURNAL OF SEPARATION SCIENCE, 2021, 页码: 16
作者:
Long, Huali
;
Yao, Shuai
;
Tian, Wenshuai
;
Hou, Jinjun
;
Lei, Min
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/01/18
chemometrics
Fraxini Cortex
high-performance thin-layer chromatography
multi-mode fingerprint
ultra-high-performance liquid chromatography
Synthesis and antiviral activity of 2 '-deoxy-6 '-substituted carbocyclic nucleosides
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2021, 页码: 12
作者:
Xue, Haitao
;
Guo, Shuang
;
Hu, Tianwen
;
Wei, Daibao
;
Xie, Yuanchao
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2022/01/18
2 '-deoxy carbocyclic nucleoside
antiviral activity
hepatitis B virus
Mitsunobu reaction
Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 6
作者:
Yang, Xiangbo
;
Lu, Huimin
;
Xie, Hang
;
Zhang, Binbin
;
Nie, Tianqing
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/01/18
Binding studies
Drug discovery
Necroptosis
RIPK1 inhibitors
Sepsis
LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo
期刊论文
CANCER SCIENCE, 2021, 页码: 12
作者:
Liu, Yingqiang
;
Lai, Mengzhen
;
Li, Shan
;
Wang, Yanan
;
Feng, Fang
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2022/01/18
C797S
epidermal growth factor receptor
fourth-generation EGFR TKI
non-small cell lung cancer
osimertinib resistance
Accucopy: accurate and fast inference of allele-specific copy number alterations from low-coverage low-purity tumor sequencing data
期刊论文
BMC BIOINFORMATICS, 2021, 卷号: 22, 期号: 1, 页码: 18
作者:
Fan, Xinping
;
Luo, Guanghao
;
Huang, Yu S.
收藏
  |  
浏览/下载:216/0
  |  
提交时间:2021/05/24
Cancer genomics
Copy number alterations
Next-generation sequencing
A camptothecin-based, albumin-binding prodrug enhances efficacy and safety in vivo
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 226, 页码: 11
作者:
Cheng, Zhiyang
;
Huang, Ying
;
Shen, Qianqian
;
Zhao, Yangrong
;
Wang, Lei
收藏
  |  
浏览/下载:86/0
  |  
提交时间:2021/11/04
Cancer
beta-glucuronidase
Bioconjugation
Albumin
Camptothecin
Conformational polymorphs of isotretinoin and their impact on physicochemical and biological properties
期刊论文
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 卷号: 610, 页码: 10
作者:
Cheng, Yinxiang
;
Rong, Xiaoyi
;
Xia, Mengyuan
;
Zhang, Zaiyong
;
Wang, Jian-Rong
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2022/01/04
Polymorph
Isotretinoin
Stability
Solubility
Bioavailability
Acceptor engineering of small-molecule fluorophores for NIR-II fluorescence and photoacoustic imaging
期刊论文
JOURNAL OF MATERIALS CHEMISTRY B, 2021, 卷号: 9, 期号: 48, 页码: 9951-9960
作者:
Li, Yaxi
;
Zhou, Hongli
;
Bi, Renzhe
;
Li, Xiuting
;
Zha, Menglei
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2022/01/04
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