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科研机构
上海药物研究所 [47]
内容类型
期刊论文 [47]
发表日期
2020 [2]
2019 [3]
2018 [7]
2017 [3]
2016 [3]
2015 [1]
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An optically active isochroman-2H-chromene conjugate potently suppresses neuronal oxidative injuries associated with the PI3K/Akt and MAPK signaling pathways
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Tao, Ling-xue
;
Ji, Sha-sha
;
Szaloki, Dora
;
Kovacs, Tibor
;
Mandi, Attila
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
neurodegeneration
oxidative stress
apoptosis
MAPK pathway
PI3K
Akt pathway
SH-SY5Y neuroblastoma cells
Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8
作者:
Li, Man
;
Li, Shi-chun
;
Dou, Bao-kai
;
Zou, Ying-xiang
;
Han, Hao-zhen
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/01
cycloastragenol
SIRT1
apoptosis
neuroinflammation
cerebral ischemia
Neuroprotective Effect of Natural Alkaloid Fangchinoline Against Oxidative Glutamate Toxicity: Involvement of Keap1-Nrf2 Axis Regulation
期刊论文
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2019, 卷号: 39, 期号: 8, 页码: 1177-1186
作者:
Bao, Fengxia
;
Tao, Lingxue
;
Zhang, Haiyan
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
Fangchinoline
Keap1
Nrf2
Oxidative stress
Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice
期刊论文
JOURNAL OF ENDOCRINOLOGY, 2019, 卷号: 240, 期号: 2, 页码: 195-214
作者:
Du, Te
;
Yang, Liu
;
Xu, Xu
;
Shi, Xiaofan
;
Xu, Xin
收藏
  |  
浏览/下载:102/0
  |  
提交时间:2019/01/08
vincamine
GPR40
beta-cell function
insulin secretion
type 2 diabetes
a11anoveldiarylacylhydrazonederivativeexertsneuroprotectionagainstischemicinjuryinvitroandinvivo
期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 2, 页码: 160
作者:
Feng Hongxuan
;
Li Chunpu
;
Shu Shuangjie
;
Liu Hong
;
Zhang Haiyan
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/07/01
FOCAL CEREBRAL-ISCHEMIA
OXIDATIVE STRESS
DRUG DISCOVERY
COLORIMETRIC ASSAY
TREAT STROKE
MECHANISMS
DISEASE
OXYGEN
PROTECTS
MODELS
ischemic stroke
neuroprotection
diaryl acylhydrazone
oxygen glucose deprivation
middle cerebral artery occlusion
protein kinase B
extracellular signal-regulated kinase
Cognitive Impairment and Endoplasmic Reticulum Stress Induced by Repeated Short-Term Sevoflurane Exposure in Early Life of Rats
期刊论文
FRONTIERS IN PSYCHIATRY, 2018, 卷号: 9
作者:
Shen, Fu-Yi
;
Song, Ying-Cai
;
Guo, Fei
;
Xu, Zhen-Dong
;
Li, Qian
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  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
sevoflurane
repeated exposure
cognitive dysfunction
synaptic plasticity
endoplasmic reticulum stress
A11, a novel diaryl acylhydrazone derivative, exerts neuroprotection against ischemic injury in vitro and in vivo
期刊论文
Acta pharmacologica Sinica, 2018
作者:
Feng, Hong-Xuan
;
Li, Chun-Pu
;
Shu, Shuang-Jie
;
Liu, Hong
;
Zhang, Hai-Yan
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  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
Humanin decreases mitochondrial membrane permeability by inhibiting the membrane association and oligomerization of Bax and Bid proteins
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 6, 页码: 1012-1021
作者:
Ma, Ze-wei
;
Liu, Dong-xiang
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
Alzheimer's disease
humanin
Bcl-2 family
mitochondrial outer membrane
single-molecule fluorescence
The PGC-1 alpha Activator ZLN005 Ameliorates Ischemia-Induced Neuronal Injury In Vitro and In Vivo
期刊论文
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2018, 卷号: 38, 期号: 4, 页码: 929-939
作者:
Xu, Yazhou
;
Kabba, John Alimamy
;
Ruan, Wenchen
;
Wang, Yunjie
;
Zhao, Shunyi
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2019/01/08
Ischemic stroke
PGC-1 alpha
HO-1
Neuroprotection
TRPM7 in CHBP-induced renoprotection upon ischemia reperfusion-related injury
期刊论文
SCIENTIFIC REPORTS, 2018, 卷号: 8
作者:
Liu, Aifen
;
Wu, Jing
;
Yang, Cheng
;
Wu, Yuanyuan
;
Zhang, Yufang
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2019/01/08
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