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科研机构
上海药物研究所 [58]
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期刊论文 [55]
会议论文 [3]
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2021 [4]
2020 [3]
2019 [7]
2018 [7]
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2016 [5]
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NIR-II imaging of hepatocellular carcinoma based on a humanized anti-GPC3 antibody
期刊论文
RSC MEDICINAL CHEMISTRY, 2021, 页码: 8
作者:
Shi, Hui
;
Huttad, Lakshmi Vageesh
;
Tan, Mingdian
;
Liu, Hongguang
;
Chua, Mei-Sze
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/01/04
ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker
期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 卷号: 6, 期号: 1, 页码: 9
作者:
Chen, Yuning
;
Zhang, Ya-Nan
;
Yan, Renhong
;
Wang, Guifeng
;
Zhang, Yuanyuan
收藏
  |  
浏览/下载:67/0
  |  
提交时间:2021/11/04
Liquid chromatography-mass spectrometry method for the quantification of an anti-sclerostin monoclonal antibody in cynomolgus monkey serum
期刊论文
JOURNAL OF PHARMACEUTICAL ANALYSIS, 2021, 卷号: 11, 期号: 4, 页码: 472-479
作者:
Gao, Yuxiong
;
Chen, Zhendong
;
Yang, Changyong
;
Zhong, Dafang
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/11/04
Anti-sclerostin monoclonal antibody (SHR-1222)
LC-MS/MS
Anti-drug antibody
Toxicokinetic
Discovery of a novel, potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumour efficacy
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2021, 页码: 20
作者:
Liu, Chenglong
;
Zhou, Feilong
;
Yan, Ziqin
;
Shen, Lian
;
Zhang, Xichen
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/06/11
immunotherapy
PD-1/PD-L1
TGF-beta
tumour immune microenvironment
Immune Checkpoint Blockade in Cancer Immunotherapy: Mechanisms, Clinical Outcomes, and Safety Profiles of PD-1/PD-L1 Inhibitors
期刊论文
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, 2020, 卷号: 68, 期号: 6, 页码: 15
作者:
Yan, Yan
;
Zhang, Li
;
Zuo, Yun
;
Qian, Heya
;
Liu, Chang
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/05/24
Immune checkpoints
PD-1
PD-L1
Monoclonal antibody
Immunotherapy
An antibody-drug conjugate targeting a GSTA glycosite-signature epitope of MUC1 expressed by non-small cell lung cancer
期刊论文
CANCER MEDICINE, 2020, 页码: 12
作者:
Pan, Deng
;
Tang, Yubo
;
Tong, Jiao
;
Xie, Chengmei
;
Chen, Jiaxi
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/12/24
Thermostability detection and optimization of glycoengineered antibodies and antibody-drug conjugates based on differential scanning flouremitry analysis
期刊论文
BIOORGANIC CHEMISTRY, 2020, 卷号: 94, 页码: 10
作者:
Qin, Ken
;
Shi, Wei
;
Zhao, Lei
;
Li, Mingjie
;
Tang, Yubo
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2020/07/01
DSF
Thermostability
Glycosylation
Glyco-engineered antibodies
ADCs
Two validated liquid chromatography-mass spectrometry methods with different pretreatments for the quantification of an anti-CD47 monoclonal antibody in rat and cynomolgus monkey serum compared with an electrochemiluminescence method
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 175, 页码: 11
作者:
Gao, Yuxiong
;
Zhang, Dan
;
Yang, Changyong
;
Duan, Xiaotao
;
Li, Xiuli
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
Anti-CD47 monoclonal antibody
LC-MS
Adsorption issue
Electrochemiluminescence
Pharmacokinetics
Cross-validation
SHR-A1403, a novel c-mesenchymal-epithelial transition factor (c-Met) antibody-drug conjugate, overcomes AZD9291 resistance in non-small cell lung cancer cells overexpressing c-Met
期刊论文
CANCER SCIENCE, 2019, 页码: 11
作者:
Tong, Mengya
;
Gao, Mingzhao
;
Xu, Yongping
;
Fu, Li
;
Li, Yun
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
AZD9291
c-Met ADC
c-Met overexpression
resistance
SHR-A1403
Trained Macrophage Bioreactor for Penetrating Delivery of Fused Antitumor Protein
期刊论文
ACS APPLIED MATERIALS & INTERFACES, 2019, 卷号: 11, 期号: 26, 页码: 23018-23025
作者:
Zhang, Yu
;
Zhang, Yujie
;
Guo, Qin
;
Guo, Zhongyuan
;
Chen, Xinli
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/01
macromolecular protein delivery
cell vector
tumor targeting
intratumoral drug distribution
breast cancer therapy
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