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科研机构
上海药物研究所 [87]
内容类型
期刊论文 [86]
会议论文 [1]
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2021 [3]
2020 [6]
2019 [8]
2018 [5]
2017 [15]
2016 [5]
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GADD45 beta stabilized by direct interaction with HSP72 ameliorates insulin resistance and lipid accumulation
期刊论文
PHARMACOLOGICAL RESEARCH, 2021, 卷号: 173, 页码: 11
作者:
Dong, Yunxia
;
Ma, Ningning
;
Fan, Lei
;
Yuan, Luyang
;
Wu, Qian
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2021/12/16
Non-alcoholic fatty liver disease
GADD45 beta
HSP72
Lipid accumulation
Insulin resistance
Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution
期刊论文
CELL REPORTS, 2021, 卷号: 36, 期号: 4, 页码: 22
作者:
Gao, Mengqing
;
Wang, Jin
;
Rousseaux, Sophie
;
Tan, Minjia
;
Pan, Lulu
收藏
  |  
浏览/下载:67/0
  |  
提交时间:2021/11/04
Histamine activates HinK to promote the virulence of Pseudomonas aeruginosa
期刊论文
SCIENCE BULLETIN, 2021, 卷号: 66, 期号: 11, 页码: 1101-1118
作者:
Wang, Yaya
;
Cao, Qiao
;
Cao, Qin
;
Gan, Jianhua
;
Sun, Ning
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/08/17
Pseudomonas aeruginosa
Histamine
Metabolism
Host-microbe interaction
Virulence
Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein
期刊论文
ONCOGENE, 2020, 页码: 14
作者:
Qian, Wenli
;
Li, Qi
;
Wu, Xinglong
;
Li, Wenguo
;
Li, Qiwei
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  |  
浏览/下载:34/0
  |  
提交时间:2020/12/21
Alteration of protein homeostasis mediates the interaction of Pseudomonas aeruginosa with Staphylococcus aureus
期刊论文
MOLECULAR MICROBIOLOGY, 2020, 页码: 20
作者:
Yang, Nana
;
Cao, Qiao
;
Hu, Shuyang
;
Xu, Chenchen
;
Fan, Ke
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  |  
浏览/下载:130/0
  |  
提交时间:2020/07/01
ClpXP
microbial interspecies interactions
proteolysis
Pseudomonas aeruginosa
quorum sensing
Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment
期刊论文
SCIENCE ADVANCES, 2020, 卷号: 6, 期号: 18, 页码: 11
作者:
Wang, Leiming
;
Cheng, Chiang-Min
;
Qin, Jun
;
Xu, Mafei
;
Kao, Chung-Yang
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/01
A Network-Based Approach to Explore the Mechanisms of Uncaria Alkaloids in Treating Hypertension and Alleviating Alzheimer's Disease
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 卷号: 21, 期号: 5, 页码: 19
作者:
Wu, Wenyong
;
Zhang, Zijia
;
Li, Feifei
;
Deng, Yanping
;
Lei, Min
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/07/01
Uncaria alkaloids
network pharmacology
hypertension
Alzheimer's disease
butyrylcholinesterase
molecular docking
Quantitative Proteomics Reveals the Protective Effects of Huangqi Decoction Against Acute Cholestatic Liver Injury by Inhibiting the NF-kappa B/IL-6/STAT3 Signaling Pathway
期刊论文
JOURNAL OF PROTEOME RESEARCH, 2020, 卷号: 19, 期号: 2, 页码: 677-687
作者:
Wu, Jia-Sheng
;
Liu, Qian
;
Fang, Shan-Hua
;
Liu, Xing
;
Zheng, Min
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
intrahepatic cholestasis
Huangqi decoction
proteomics
NF-kappa B
IL-6
STAT3
The Development of Inhibitors Targeting the Mixed Lineage Leukemia 1 (MLL1)-WD Repeat Domain 5 Protein (WDR5) Protein-Protein Interaction
期刊论文
CURRENT MEDICINAL CHEMISTRY, 2020, 卷号: 27, 期号: 33, 页码: 5530-5542
作者:
Ye, Xiaoqing
;
Chen, Gang
;
Jin, Jia
;
Zhang, Binzhong
;
Wang, Yinda
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/12/24
WDR5
MLL1
histone methyltransferase
small-molecular inhibitor
epigenetics
human acute leukemia
Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 15
作者:
收藏
  |  
浏览/下载:94/0
  |  
提交时间:2020/07/01
Hippo pathway
TEAD transcription factor
Covalent inhibitor
Palmitoylation inhibitor
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