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科研机构
上海药物研究所 [24]
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期刊论文 [22]
会议论文 [2]
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2020 [5]
2019 [3]
2018 [5]
2017 [3]
2016 [3]
2015 [1]
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SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways
期刊论文
CANCER CELL, 2020, 卷号: 38, 期号: 3, 页码: 350-+
作者:
Yuan, Huairui
;
Han, Ying
;
Wang, Xuege
;
Li, Ni
;
Liu, Qiuli
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/12/24
Identification of catalytic and non-catalytic activity inhibitors against PRC2-EZH2 complex through multiple high-throughput screening campaigns
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2020, 页码: 27
作者:
Zhou, Yan
;
Du, Dao-Hai
;
Wang, Jia
;
Cai, Xiao-Qing
;
Deng, Alicia X.
收藏
  |  
浏览/下载:103/0
  |  
提交时间:2020/07/01
embryonic ectoderm development
Enhancer of zeste homolog 2
fluorescence polarization
high-throughput screening
homogenous time-resolved fluorescence
inhibitor
polycomb repressive complex 2
EZH2 inhibitors abrogate upregulation of trimethylation of H3K27 by CDK9 inhibitors and potentiate its activity against diffuse large B-cell lymphoma
期刊论文
HAEMATOLOGICA, 2020, 卷号: 105, 期号: 4, 页码: 1021-1031
作者:
Xie, Shao
;
Wei, Fan
;
Sun, Yi-ming
;
Gao, Ying-lei
;
Pan, Lu-lu
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/01
Global characterization of proteome and lysine methylome features in EZH2 wild-type and mutant lymphoma cell lines
期刊论文
JOURNAL OF PROTEOMICS, 2020, 卷号: 213, 页码: 10
作者:
Hao, Bingbing
;
Sun, Mingwei
;
Zhang, Min
;
Zhao, Xiaoxiao
;
Zhao, Lei
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/01
Lysine methylome
Quantitative proteomics
EZH2
Diffuse large B cell lymphoma
PTM crosstalk
Identification and Assessments of Novel and Potent Small-Molecule Inhibitors of EED-EZH2 Interaction of Polycomb Repressive Complex 2 by Computational Methods and Biological Evaluations
期刊论文
CHEMICAL & PHARMACEUTICAL BULLETIN, 2020, 卷号: 68, 期号: 1, 页码: 58-63
作者:
Zhu, Kongkai
;
Du, Daohai
;
Yang, Rui
;
Tao, Hongrui
;
Zhang, Hua
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
polycomb repressive complex 2
EZH2-EED interaction inhibitor
virtual screening
molecular dynamics simulation
AZD9291 inactivates the PRC2 complex to mediate tumor growth inhibition
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1587-1595
作者:
Zhang, Kai-li
;
Shen, Qian-qian
;
Fang, Yan-fen
;
Sun, Yi-ming
;
Ding, Jian
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
PRC2
EZH2-EED
AZD9291
miR-34a
non-canonical base pairing
Inhibition of Ezh2 In Vitro and the Decline of Ezh2 in Developing Midbrain Promote Dopaminergic Neurons Differentiation Through Modifying H3K27me3
期刊论文
STEM CELLS AND DEVELOPMENT, 2019, 卷号: 28, 期号: 10, 页码: 649-658
作者:
Hong, Feng
;
Zhao, Mengxue
;
Zhang, Lei
;
Feng, Linyin
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
dopaminergic neurons
Ezh2
Nurr1
neural stem cells
Deep Neural Network Classifier for Virtual Screening Inhibitors of (S)-Adenosyl-L-Methionine (SAM)-Dependent Methyltransferase Family
期刊论文
FRONTIERS IN CHEMISTRY, 2019, 卷号: 7, 页码: 17
作者:
Li, Fei
;
Wan, Xiaozhe
;
Xing, Jing
;
Tan, Xiaoqin
;
Li, Xutong
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
deep neural network
virtual screening
methyltransferase
epigenetic
drug design
Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors
期刊论文
CELL, 2018, 卷号: 175, 期号: 1, 页码: 186-+
作者:
Huang, Xun
;
Yan, Juan
;
Zhang, Min
;
Wang, Yafang
;
Chen, Yi
收藏
  |  
浏览/下载:77/0
  |  
提交时间:2019/01/08
EZH2 inhibitors abrogate upregulation of H3K27me3 by CDK9 inhibitors and potentiate its antitumor activity in DLBCL
期刊论文
CANCER RESEARCH, 2018, 卷号: 78, 期号: 13, 页码: 2
作者:
Xie, Shao
;
Wei, Fan
;
Sun, Yiming
;
Gao, Yinglei
;
Ding, Jian
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/07/01
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