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上海药物研究所 [17]
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期刊论文 [26]
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2020 [26]
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Pharmacolo... [1]
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Modulation of the G-Protein-Coupled Receptor 84 (GPR84) by Agonists and Antagonists
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 24, 页码: 15399-15409
作者:
Chen, Lin-Hai
;
Zhang, Qing
;
Xie, Xin
;
Nan, Fa-Jun
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2021/05/24
Targeted Proteomics Combined with Affinity Mass Spectrometry Analysis Reveals Antagonist E7 Acts As an Intracellular Covalent Ligand of Orphan Receptor GPR52
期刊论文
ACS CHEMICAL BIOLOGY, 2020, 卷号: 15, 期号: 12, 页码: 3275-3284
作者:
Ma, Mengna
;
Guo, Shimeng
;
Lin, Xi
;
Li, Shanshan
;
Wu, Yiran
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2021/05/24
Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (ROR gamma t) modulators: insights into different protein behaviors with "short" and "long" inverse agonists
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Yu, Ming-cheng
;
Yang, Feng
;
Ding, Xiao-yu
;
Sun, Nan-nan
;
Jiang, Zheng-yuan
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2020/12/24
RORγ
t
cocrystal structures
MD simulation
“
short”
inverse agonists
agonists
“
long”
inverse agonists
Discovery and Optimization of Non-bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic Steatohepatitis
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 21, 页码: 12748-12772
作者:
Li, Junyou
;
Liu, Mengqi
;
Li, Yazhou
;
Sun, Dan-dan
;
Shu, Zhihao
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/05/24
Design of G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) soft drugs with reduced gallbladder-filling effects
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 12
作者:
Han, Fanghui
;
Ning, Mengmeng
;
Cao, Hua
;
Ye, Yangliang
;
Feng, Ying
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/12/21
Soft drug
TGR5
GLP-1
Gallbladder-filling effects
Rapid metabolism
Carboxylic ester
Evaluation of biased agonism mediated by dual agonists of the GLP-1 and glucagon receptors
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 180, 页码: 16
作者:
Darbalaei, Sanaz
;
Yuliantie, Elita
;
Dai, Antao
;
Chang, Rulue
;
Zhao, Peishen
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/12/21
G protein-coupled receptor
Glucagon-like peptide-1 receptor
Glucagon receptor
Biased agonism
Unimolecular dual agonist
A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation
期刊论文
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE, 2020, 卷号: 2020, 页码: 13
作者:
Li, Licong
;
Zhou, Jin
;
Sun, Hongji
;
Liu, Jing
;
Wang, Hongrui
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/01/07
GPR91, a critical signaling mechanism in modulating pathophysiologic processes in chronic illnesses
期刊论文
FASEB JOURNAL, 2020, 页码: 15
作者:
Li, Xinyi
;
Xie, Li
;
Qu, Xiangli
;
Zhao, Bangyi
;
Fu, Wei
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/12/24
G protein-coupled receptor
innate immunity
metabolic regulation
succinate
SUCNR1
Mechanistic in silico modeling of bisphenols to predict estrogen and glucocorticoid disrupting potentials
期刊论文
SCIENCE OF THE TOTAL ENVIRONMENT, 2020, 卷号: 728, 页码: 1-11
作者:
Chen, Qinchang
;
Zhou, Chengzhuo
;
Shi, Wei
;
Wang, Xiaoxiang
;
Xia, Pu
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/09/14
Endocrine disruptor
Estrogen receptor
Glucocorticoid receptor
Coregulators
Accelerated molecular dynamics simulations
Binding free energy
Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 28, 页码: 9313-9325
作者:
Chang, Rulue
;
Zhang, Xin
;
Qiao, Anna
;
Dai, Antao
;
Belousoff, Matthew J.
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2020/12/24
glucagon receptor
glucagon-like peptide-1 receptor
dual agonist
cryo-electron microscopy
single particle analysis
structure-function
structural biology
peptide 15 (P15)
metabolic disorder
G protein?coupled receptor (GPCR)
glucagon
GLP-1 receptor
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