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山东大学 [29]
复旦大学上海医学院 [16]
湖南大学 [15]
上海药物研究所 [10]
上海中医药大学 [6]
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期刊论文 [124]
会议论文 [1]
学位论文 [1]
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2019 [126]
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An "Amyloid-beta Cleaner" for the Treatment of Alzheimer's Disease by Normalizing Microglial Dysfunction
期刊论文
ADVANCED SCIENCE, 2019, 页码: 12
作者:
Liu, Ruiyuan
;
Yang, Jun
;
Liu, Linying
;
Lu, Zhiguo
;
Shi, Zhuyan
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/03/24
Alzheimer's Disease
a Beta
Microglia
Neuroinflammation
Phagocytosis
Altered Cerebro-Cerebellar Limbic Network in AD Spectrum: A Resting-State fMRI Study
期刊论文
FRONTIERS IN NEURAL CIRCUITS, 2019, 卷号: 13, 页码: 9
作者:
Qi, Zhigang
;
An, Yanhong
;
Zhang, Mo
;
Li, Hui-Jie
;
Lu, Jie
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/02/29
mild cognitive impairment
Alzheimer's disease
cerebro-cerebellar connectivity
limbic network
resting-state functional MRI
compensation
Structural Mechanism of Barriers to Interspecies Seeding Transmissibility of Full-Length Prion Protein Amyloid
期刊论文
CHEMBIOCHEM, 2019, 卷号: 20, 期号: 21, 页码: 2757-2766
作者:
Ma, Tao
;
Deng, Jing
;
Ma, Shaojie
;
Zhao, Weijing
;
Chang, Ziwei
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
amyloid fibrils
molecular dynamics
NMR spectroscopy
prions
seeding
species barriers
Molecular Mechanism of Binding Selectivity of Inhibitors toward BACE1 and BACE2 Revealed by Multiple Short Molecular Dynamics Simulations and Free-Energy Predictions
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 10, 页码: 4303-4318
作者:
Chen, Jianzhong
;
Wang, Jinan
;
Yin, Baohua
;
Pang, Laixue
;
Wang, Wei
收藏
  |  
浏览/下载:114/0
  |  
提交时间:2020/07/01
beta-amyloid cleaving enzyme
binding selectivity
MSMD
hierarchical clustering analysis
MM-GBSA
Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression
期刊论文
CELL RESEARCH, 2019, 卷号: 29, 期号: 10, 页码: 787-803
作者:
Wang, Xinyi
;
Sun, Guangqiang
;
Feng, Teng
;
Zhang, Jing
;
Huang, Xun
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2020/07/01
Interplay between Alzheimer's disease and global glucose metabolism revealed by the metabolic profile alterations of pancreatic tissue and serum in APP/PS1 transgenic mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 10, 页码: 1259-1268
作者:
Liu, Xia
;
Wang, Wei
;
Chen, Hua-li
;
Zhang, Hai-yan
;
Zhang, Nai-xia
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
Alzheimer's disease
type 2 diabetes
APP/PS1 transgenic mice
metabolomics
NMR
glucose metabolism dysfunctions
Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 10, 页码: 1279-1291
作者:
Fan, Lei
;
Qiu, Xiao-xia
;
Zhu, Zhi-yuan
;
Lv, Jian-lu
;
Lu, Jian
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
Alzheimer's disease
nitazoxanide
autophagy
inflammation
APP/PS1 transgenic mice
Nature brings new avenues to the therapy of central nervous system diseases-An overview of possible treatments derived from natural products
期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2019, 卷号: 62, 期号: 10, 页码: 1332-1367
作者:
Zhang, Junchi
;
He, Yang
;
Jiang, Xiangrui
;
Jiang, Hualiang
;
Shen, Jingshan
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/01
natural products
traditional Chinese medicine
central nervous system diseases
treatment
Exploiting mammalian low-complexity domains for liquid-liquid phase separation-driven underwater adhesive coatings
期刊论文
SCIENCE ADVANCES, 2019, 卷号: 5, 期号: 8
作者:
Cui, Mengkui
;
Wang, Xinyu
;
An, Bolin
;
Zhang, Chen
;
Gui, Xinrui
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2019/12/26
All-atom structure ensembles of islet amyloid polypeptides determined by enhanced sampling and experiment data restraints
期刊论文
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2019, 卷号: 87, 期号: 7, 页码: 541-550
作者:
Su, Xinyue
;
Wang, Ke
;
Liu, Na
;
Chen, Jiawen
;
Li, Yong
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2019/10/14
aggregation
chemical shift restraint
islet amylod polypeptide
metadynamics
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