VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex

	VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex
	Zhang, WJ; Gao, YJ; Li, PX; Shi, ZB; Guo, T; Li, F; Han, XK; Feng, Y; Zheng, C; Wang, ZY
刊名	CELL RESEARCH
	2014
卷号	24 期号:3 页码:331-343
关键词	VGLL4 lung cancer Hippo pathway YAP
通讯作者	Ji, HB (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Yueyang Rd, Shanghai 200031, Peoples R China.,zczhou@sibcb.ac.cn ; RayZhang@sibcb.ac.cn ; hbji@sibcb.ac.cn
英文摘要	Lung cancer is one of the most devastating diseases worldwide with high incidence and mortality. Hippo (Hpo) pathway is a conserved regulator of organ size in both Drosophila and mammals. Emerging evidence has suggested the significance of Hpo pathway in cancer development. In this study, we identify VGLL4 as a novel tumor suppressor in lung carcinogenesis through negatively regulating the formation of YAP-TEAD complex, the core component of Hpo pathway. Our data show that VGLL4 is frequently observed to be lowly expressed in both mouse and human lung cancer specimens. Ectopic expression of VGLL4 significantly suppresses the growth of lung cancer cells in vitro. More importantly, VGLL4 significantly inhibits lung cancer progression in de novo mouse model. We further find that VGLL4 inhibits the activity of the YAP-TEAD transcriptional complex. Our data show that VGLL4 directly competes with YAP in binding to TEADs and executes its growth-inhibitory function through two TDU domains. Collectively, our study demonstrates that VGLL4 is a novel tumor suppressor for lung cancer through negatively regulating the YAP-TEAD complex formation and thus the Hpo pathway.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	YES-ASSOCIATED PROTEIN ; ORGAN SIZE CONTROL ; HIPPO PATHWAY ; GROWTH-CONTROL ; HEPATOCELLULAR-CARCINOMA ; GENE-EXPRESSION ; TISSUE-GROWTH ; PROGRESSION ; COFACTORS ; ONCOGENE
收录类别	SCI
语种	英语
WOS记录号	WOS:000332246500009
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/162]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhang, WJ,Gao, YJ,Li, PX,et al. VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex[J]. CELL RESEARCH,2014,24(3):331-343.
APA	Zhang, WJ.,Gao, YJ.,Li, PX.,Shi, ZB.,Guo, T.,...&Ji, HB.(2014).VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex.CELL RESEARCH,24(3),331-343.
MLA	Zhang, WJ,et al."VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex".CELL RESEARCH 24.3(2014):331-343.