Neurovascular Recovery via Cotransplanted Neural and Vascular Progenitors Leads to Improved Functional Restoration after Ischemic Stroke in Rats

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	Neurovascular Recovery via Cotransplanted Neural and Vascular Progenitors Leads to Improved Functional Restoration after Ischemic Stroke in Rats
	Li, J ; Tang, YH ; Wang, YT ; Tang, RB ; Jiang, WF ; Yang, GY ; Gao, WQ
刊名	STEM CELL REPORTS
	2014
卷号	3 期号:1 页码:1111-1111
关键词	STEM-CELLS IN-VIVO POPULATION MECHANISMS MATURATION DEFICITS THERAPY SCIENCE INJURY
ISSN号	2213-6711
通讯作者	Yang, GY (reprint author), Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200030, Peoples R China.,gyyang0626@gmail.com ; gao.weiqiang@sjtu.edu.cn
英文摘要	The concept of the "neurovascular unit,'' emphasizing the interactions between neural and vascular components in the brain, raised the notion that neural progenitor cell (NPC) transplantation therapy aimed at neural repair may be insufficient for the treatment of ischemic stroke. Here, we demonstrate that enhanced neurovascular recovery via cotransplantation of NPCs and embryonic stem cell-derived vascular progenitor cells (VPCs) in a rat stroke model is correlated with improved functional recovery after stroke. We found that cotransplantation promoted the survival, migration, differentiation, and maturation of neuronal and vascular cells derived from the cotransplanted progenitors. Furthermore, it triggered an increased generation of VEGF-, BDNF-, and IGF1-expressing neural cells derived from the grafted NPCs. Consistently, compared with transplantation of NPCs alone, cotransplantation more effectively improved the neurobehavioral deficits and attenuated the infarct volume. Thus, cotransplantation of NPCs and VPCs represents a more effective therapeutic strategy for the treatment of stroke than transplantation of NPCs alone.
学科主题	Cell & Tissue Engineering ; Cell Biology
收录类别	SCI
资助信息	Chinese Ministry of Science and Technology [2012CB966800, 2013CB945600, 2012CB967903, 2011CB504405]; National Natural Science Foundation of China [81130038, 81372189, 81302235, 81070939]; Key Discipline and Specialty Foundation of Shanghai Health Bureau; Science and Technology Commission of Shanghai Municipality [10JC1408100]; Shanghai Education Committee Key Discipline and Specialty Foundation [J50208]; K.C. Wong Foundation; China Postdoctoral Science Foundation [20110490737]
语种	英语
公开日期	2014-12-15
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2655]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Li, J,Tang, YH,Wang, YT,et al. Neurovascular Recovery via Cotransplanted Neural and Vascular Progenitors Leads to Improved Functional Restoration after Ischemic Stroke in Rats[J]. STEM CELL REPORTS,2014,3(1):1111-1111.
APA	Li, J.,Tang, YH.,Wang, YT.,Tang, RB.,Jiang, WF.,...&Gao, WQ.(2014).Neurovascular Recovery via Cotransplanted Neural and Vascular Progenitors Leads to Improved Functional Restoration after Ischemic Stroke in Rats.STEM CELL REPORTS,3(1),1111-1111.
MLA	Li, J,et al."Neurovascular Recovery via Cotransplanted Neural and Vascular Progenitors Leads to Improved Functional Restoration after Ischemic Stroke in Rats".STEM CELL REPORTS 3.1(2014):1111-1111.