Crystal structures of receptors involved in small molecule transport across membranes

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Crystal structures of receptors involved in small molecule transport across membranes
	Bulut, Haydar ; Ma, Qingjun ; Moniot, Sebastien ; Saenger, Wolfram ; Schneider, Erwin ; Vahedi-Faridi, Ardeschir
刊名	EUROPEAN JOURNAL OF CELL BIOLOGY
	2012-04
卷号	91 期号:4 页码:318-325
关键词	Crystallography ABC transporter Acarbose Galactose Arginine Lysine Histidine Cysteine Cystine MALTOSE-BINDING PROTEIN SOLUTE RECEPTOR MALTODEXTRIN TRANSPORT ACARBOSE SYSTEM
中文摘要	This paper briefly reviews contemporary protein crystallography and focuses on six receptor proteins of membrane-intrinsic ATP binding cassette (ABC) transporters. Three of these receptors are specific for carbohydrates and three for amino acids. The receptor GacH of the transporter GacFGH from Streptomyces glaucescens is specific for acarbose and its homologs, and MalE of Salmonella typhimurium is specific for maltose but also forms a complex with acarbose, and the third receptor is the highly specific D-galactose receptor AcbH of the transporter AcbFGH from Actinoplanes sp. Concerning the receptors for amino acids, ArtJ belongs to the ArtJ-(MP)(2) transporter of Geobacillus stearotermophilus and recognizes and binds to positively charged arginine, lysine, and histidine with different sizes of side chains, contrasting the receptors Ngo0372 and Ngo2014 from Neisseria gonorrhaeae that are highly specific for cystine and cysteine, respectively. The differences in the rather unspecific receptors GacH, MalE and ArtJ are compared with the highly specific receptors AcbH, Ngo0372 and Ngo2014.
收录类别	SCI
语种	英语
公开日期	2014-09-08
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/18198]
专题	海洋研究所_实验海洋生物学重点实验室
推荐引用方式 GB/T 7714	Bulut, Haydar,Ma, Qingjun,Moniot, Sebastien,et al. Crystal structures of receptors involved in small molecule transport across membranes[J]. EUROPEAN JOURNAL OF CELL BIOLOGY,2012,91(4):318-325.
APA	Bulut, Haydar,Ma, Qingjun,Moniot, Sebastien,Saenger, Wolfram,Schneider, Erwin,&Vahedi-Faridi, Ardeschir.(2012).Crystal structures of receptors involved in small molecule transport across membranes.EUROPEAN JOURNAL OF CELL BIOLOGY,91(4),318-325.
MLA	Bulut, Haydar,et al."Crystal structures of receptors involved in small molecule transport across membranes".EUROPEAN JOURNAL OF CELL BIOLOGY 91.4(2012):318-325.