Targeting cellular apoptotic pathway with peptides from marine organisms

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	Targeting cellular apoptotic pathway with peptides from marine organisms
	Zheng, Lanhong 1; Lin, Xiukun 2; Wu, Ning 3; Liu, Ming 3; Zheng, Yuan 1; Sheng, Jun 1; Ji, Xiaofeng 1; Sun, Mi 1
刊名	BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
	2013-08-01
卷号	1836 期号:1 页码:42-48
关键词	Apoptosis Marine organisms Peptides
ISSN号	0304-419X
通讯作者	Lin, XK
中文摘要	Apoptosis is a critical defense mechanism against the formation and progression of cancer and exhibits distinct morphological and biochemical traits. Targeting apoptotic pathways becomes an intriguing strategy for the development of chemotherapeutic agents. Peptides from marine organisms have become important sources in the discovery of antitumor drugs, especially when modern technology makes it more and more feasible to collect organisms from seas. This primer summarizes several marine peptides, based on their effects on apoptotic signaling pathways, although most of these peptides have not yet been studied in depth for their mechanisms of action. Novel peptides that induce an apoptosis signal pathway are presented in association with their pharmacological properties. (C) 2013 Elsevier B.V. All rights reserved.
英文摘要	Apoptosis is a critical defense mechanism against the formation and progression of cancer and exhibits distinct morphological and biochemical traits. Targeting apoptotic pathways becomes an intriguing strategy for the development of chemotherapeutic agents. Peptides from marine organisms have become important sources in the discovery of antitumor drugs, especially when modern technology makes it more and more feasible to collect organisms from seas. This primer summarizes several marine peptides, based on their effects on apoptotic signaling pathways, although most of these peptides have not yet been studied in depth for their mechanisms of action. Novel peptides that induce an apoptosis signal pathway are presented in association with their pharmacological properties. (C) 2013 Elsevier B.V. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Biophysics ; Oncology
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics ; Oncology
研究领域[WOS]	Biochemistry & Molecular Biology ; Biophysics ; Oncology
关键词[WOS]	BCL-2 FAMILY PROTEINS ; FACTOR-KAPPA-B ; CANCER-THERAPY ; BRENTUXIMAB VEDOTIN ; DIDEMNIN-B ; IN-VITRO ; PM02734 ELISIDEPSIN ; SOMOCYSTINAMIDE-A ; ANTICANCER AGENTS ; CLINICAL-TRIALS
收录类别	SCI
原文出处	10.1016/j.bbcan.2013.02.006
语种	英语
WOS记录号	WOS:000320475800004
公开日期	2014-07-17
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/16639]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China 2.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Lanhong,Lin, Xiukun,Wu, Ning,et al. Targeting cellular apoptotic pathway with peptides from marine organisms[J]. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER,2013,1836(1):42-48.
APA	Zheng, Lanhong.,Lin, Xiukun.,Wu, Ning.,Liu, Ming.,Zheng, Yuan.,...&Sun, Mi.(2013).Targeting cellular apoptotic pathway with peptides from marine organisms.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER,1836(1),42-48.
MLA	Zheng, Lanhong,et al."Targeting cellular apoptotic pathway with peptides from marine organisms".BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER 1836.1(2013):42-48.