Exceptionally high cumulative percentage of NUMTs originating from linear mitochondrial DNA molecules in the Hydra magnipapillata genome

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	Exceptionally high cumulative percentage of NUMTs originating from linear mitochondrial DNA molecules in the Hydra magnipapillata genome
	Song, Shen 1; Jiang, Feng 2,3; Yuan, Jianbo 4; Guo, Wei 2; Miao, Yongwang 1
刊名	BMC GENOMICS
	2013-07-04
卷号	14 页码:447
关键词	Cnidaria Mitochondrial DNA NUMT Linear mitochondrial genome
ISSN号	1471-2164
通讯作者	Jiang, F
中文摘要	Background: In contrast to most animal genomes, mitochondrial genomes in species belonging to the phylum Cnidaria show distinct variations in genome structure, including the mtDNA structure (linear or circular) and the presence or absence of introns in protein-coding genes. Therefore, the analysis of nuclear insertions of mitochondrial sequences (NUMTs) in cnidarians allows us to compare the NUMT content in animals with different mitochondrial genome structures. Results: NUMT identification in the Hydra magnipapillata, Nematostella vectensis and Acropora digitifera genomes showed that the NUMT density in the H. magnipapillata genome clearly exceeds that in other two cnidarians with circular mitochondrial genomes. We found that H. magnipapillata is an exceptional ancestral metazoan with a high NUMT cumulative percentage but a large genome, and its mitochondrial genome linearisation might be responsible for the NUMT enrichment. We also detected the co-transposition of exonic and intronic fragments within NUMTs in N. vectensis and provided direct evidence that mitochondrial sequences can be transposed into the nuclear genome through DNA-mediated fragment transfer. In addition, NUMT expression analyses showed that NUMTs are co-expressed with adjacent protein-coding genes, suggesting the relevance of their biological function. Conclusions: Taken together, our results provide valuable information for understanding the impact of mitochondrial genome structure on the interaction of mitochondrial molecules and nuclear genomes.
英文摘要	Background: In contrast to most animal genomes, mitochondrial genomes in species belonging to the phylum Cnidaria show distinct variations in genome structure, including the mtDNA structure (linear or circular) and the presence or absence of introns in protein-coding genes. Therefore, the analysis of nuclear insertions of mitochondrial sequences (NUMTs) in cnidarians allows us to compare the NUMT content in animals with different mitochondrial genome structures.
学科主题	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biotechnology & Applied Microbiology ; Genetics & Heredity
研究领域[WOS]	Biotechnology & Applied Microbiology ; Genetics & Heredity
关键词[WOS]	CLASS-LEVEL RELATIONSHIPS ; TRANSFER-RNA GENES ; KINASE-C-DELTA ; NUCLEAR GENOME ; SEGMENTAL DUPLICATIONS ; PHYLUM CNIDARIA ; TRNASCAN-SE ; EVOLUTION ; PSEUDOGENES ; SEQUENCES
收录类别	SCI
原文出处	10.1186/1471-2164-14-447
语种	英语
WOS记录号	WOS:000321861700002
公开日期	2014-07-17
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/16566]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Yunnan Agr Univ, Fac Anim Sci & Technol, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Inst Zool, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Song, Shen,Jiang, Feng,Yuan, Jianbo,et al. Exceptionally high cumulative percentage of NUMTs originating from linear mitochondrial DNA molecules in the Hydra magnipapillata genome[J]. BMC GENOMICS,2013,14:447.
APA	Song, Shen,Jiang, Feng,Yuan, Jianbo,Guo, Wei,&Miao, Yongwang.(2013).Exceptionally high cumulative percentage of NUMTs originating from linear mitochondrial DNA molecules in the Hydra magnipapillata genome.BMC GENOMICS,14,447.
MLA	Song, Shen,et al."Exceptionally high cumulative percentage of NUMTs originating from linear mitochondrial DNA molecules in the Hydra magnipapillata genome".BMC GENOMICS 14(2013):447.