Proteomic and metabolomic analysis reveal gender-specific responses of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether (BDE 47)

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室

	Proteomic and metabolomic analysis reveal gender-specific responses of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether (BDE 47)
	Ji, Chenglong1,2 ; Wu, Huifeng1 ; Wei, Lei 1,2; Zhao, Jianmin1 ; Yu, Junbao1
刊名	AQUATIC TOXICOLOGY
	2013-09-15
卷号	140 页码:449-457
关键词	BDE 47 Mytilus galloprovincialis Toxicological effects Proteomics Metabolomics
ISSN号	0166-445X
其他题名	Synthesis and Electroluminescence of Thieno-[3,4-b]pyrazine-cored Molecule with Fluorinated Shell.pdf
通讯作者	Wu, HF (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc,YICCAS, Yantai 264003, Peoples R China. hfwu@yic.ac.cn
产权排序	[Ji, Chenglong; Wu, Huifeng; Wei, Lei; Zhao, Jianmin; Yu, Junbao] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc,YICCAS, Yantai 264003, Peoples R China; [Ji, Chenglong; Wei, Lei] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
中文摘要	Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame-retardants (BFRs) that are widely used in industrial products and have posed potential risk on the coastal environment of the Laizhou Bay in China. They are of great concern due to their toxicities, such as hepatotoxicity, carcinogenecity, neurotoxicity, immunotoxicity and endocrine disrupting effects in animals. In this work, we focused on the gender-specific responses of BDE 47 in mussel Mytilus galloprovincialis using a combined proteomic and metabolomic approach. Metabolic responses indicated that BDE 47 mainly caused disturbance in energy metabolism in male mussel gills. For female mussel samples, disruption in both osmotic regulation and energy metabolism was found in terms of differential metabolic profiles. Proteomic responses revealed that BDE 47 induced cell apoptosis and reduced reactive oxygen species (ROS) production in both male and female mussels, disturbance in protein homeostasis in male mussels as well as disturbance in female mussel proteolysis based on the differential proteomic biomarkers. Overall, these results confirmed the gender-specific responses in mussels to ODE 47 exposures. This work demonstrated that an integrated metabolomic and proteomic approach could provide an important insight into the toxicological effects of environmental pollutant to organisms. (C) 2013 Elsevier B.V. All rights reserved.
英文摘要	Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame-retardants (BFRs) that are widely used in industrial products and have posed potential risk on the coastal environment of the Laizhou Bay in China. They are of great concern due to their toxicities, such as hepatotoxicity, carcinogenecity, neurotoxicity, immunotoxicity and endocrine disrupting effects in animals. In this work, we focused on the gender-specific responses of BDE 47 in mussel Mytilus galloprovincialis using a combined proteomic and metabolomic approach. Metabolic responses indicated that BDE 47 mainly caused disturbance in energy metabolism in male mussel gills. For female mussel samples, disruption in both osmotic regulation and energy metabolism was found in terms of differential metabolic profiles. Proteomic responses revealed that BDE 47 induced cell apoptosis and reduced reactive oxygen species (ROS) production in both male and female mussels, disturbance in protein homeostasis in male mussels as well as disturbance in female mussel proteolysis based on the differential proteomic biomarkers. Overall, these results confirmed the gender-specific responses in mussels to ODE 47 exposures. This work demonstrated that an integrated metabolomic and proteomic approach could provide an important insight into the toxicological effects of environmental pollutant to organisms. (C) 2013 Elsevier B.V. All rights reserved.
学科主题	Marine & Freshwater Biology ; Toxicology
研究领域[WOS]	Marine & Freshwater Biology ; Toxicology
关键词[WOS]	POLYBROMINATED DIPHENYL ETHERS ; LASER-DESORPTION/IONIZATION-TIME ; EARTHWORM EISENIA-FOETIDA ; FLAME RETARDANTS ; EXPOSURE ; PROTEIN ; CELLS ; EXPRESSION ; CHINA ; PBDES
收录类别	SCI
资助信息	Chinese Academy of Sciences [KZZD-EW-14-03]
原文出处	http://dx.doi.org/10.1016/j.aquatox.2013.07.009
语种	英语
WOS记录号	WOS:000324900800049
公开日期	2014-07-08
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/6951]
专题	烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室烟台海岸带研究所_滨海湿地实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc,YICCAS, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Ji, Chenglong,Wu, Huifeng,Wei, Lei,et al. Proteomic and metabolomic analysis reveal gender-specific responses of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether (BDE 47)[J]. AQUATIC TOXICOLOGY,2013,140:449-457.
APA	Ji, Chenglong,Wu, Huifeng,Wei, Lei,Zhao, Jianmin,&Yu, Junbao.(2013).Proteomic and metabolomic analysis reveal gender-specific responses of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether (BDE 47).AQUATIC TOXICOLOGY,140,449-457.
MLA	Ji, Chenglong,et al."Proteomic and metabolomic analysis reveal gender-specific responses of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether (BDE 47)".AQUATIC TOXICOLOGY 140(2013):449-457.