Fatty acid esters of hydroxy fatty acids: A potential treatment for obesity-related diseases

doi:10.1111/obr.13735

	Fatty acid esters of hydroxy fatty acids: A potential treatment for obesity-related diseases
	Li, Lili 1,2; Wang, Ping 1,2; Jiao, Xudong 1; Qin, Song 1; Liu, Zhengyi 1; Ye, Yanrui 3; Song, Yipeng 4,6; Hou, Hu 5,7
刊名	OBESITY REVIEWS
	2024-03-10
页码	11
关键词	adipose tissue diabetes fatty acid esters of hydroxy fatty acids inflammation structure-activity relationship
ISSN号	1467-7881
DOI	10.1111/obr.13735
通讯作者	Song, Yipeng(syp1972@sina.com) ; Hou, Hu(houhu@ouc.edu.cn)
英文摘要	Obesity, a burgeoning worldwide health system challenge, is associated with multiple chronic diseases, including diabetes and chronic inflammation. Fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified lipids with mitigating and anti-inflammatory effects in diabetes. Increasing work has shown that FAHFAs exert antioxidant activity and enhance autophagy in neuronal cells and cardiomyocytes. We systematically summarized the biological activities of FAHFAs, including their regulatory effects on diabetes and inflammation, antioxidant activity, and autophagy augmentation. Notably, the structure-activity relationships and potential biosynthesis of FAHFAs are thoroughly discussed. FAHFAs also showed potential roles as diagnostic biomarkers. FAHFAs are a class of resources with promising applications in the biomedical field that require in-depth research and hotspot development, as their structure has not been fully resolved and their biological activity has not been fully revealed.
WOS关键词	DE-NOVO LIPOGENESIS ; INSULIN-RESISTANCE ; ENERGY-METABOLISM ; OXIDATIVE STRESS ; GLUCOSE ; ADIPOCYTES ; FAHFAS ; GPR40 ; INFLAMMATION ; LIPIDOMICS
WOS研究方向	Endocrinology & Metabolism
语种	英语
WOS记录号	WOS:001181626800001
资助机构	National Key Research and Development Program
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/34907]
专题	中国科学院烟台海岸带研究所
通讯作者	Song, Yipeng; Hou, Hu
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China 2.Shandong Univ Tradit Chinese Med, Qingdao Acad Chinese Med Sci, Qingdao, Peoples R China 3.South China Univ Technol, Sch Biol & Biol Engn, Guangzhou, Peoples R China 4.Yantai Yuhuangding Hosp, Yantai, Peoples R China 5.Ocean Univ China, Qingdao, Peoples R China 6.Yantai Yuhuangding Hosp, 20 Yudong Rd, Yantai 264000, Shandong, Peoples R China 7.Ocean Univ China, 5 Yushan Rd, Qingdao 266003, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Li, Lili,Wang, Ping,Jiao, Xudong,et al. Fatty acid esters of hydroxy fatty acids: A potential treatment for obesity-related diseases[J]. OBESITY REVIEWS,2024:11.
APA	Li, Lili.,Wang, Ping.,Jiao, Xudong.,Qin, Song.,Liu, Zhengyi.,...&Hou, Hu.(2024).Fatty acid esters of hydroxy fatty acids: A potential treatment for obesity-related diseases.OBESITY REVIEWS,11.
MLA	Li, Lili,et al."Fatty acid esters of hydroxy fatty acids: A potential treatment for obesity-related diseases".OBESITY REVIEWS (2024):11.