Enhancing the sensitivity of polymeric membrane polycation-sensitive electrodes by surface modification of a polydopamine nanolayer

doi:10.1016/j.snb.2024.135310

	Enhancing the sensitivity of polymeric membrane polycation-sensitive electrodes by surface modification of a polydopamine nanolayer
	Wang, Kaikai 1,2,4; Liang, Rongning 1,2; Qin, Wei 1,2,3,5
刊名	SENSORS AND ACTUATORS B-CHEMICAL
	2024-04-15
卷号	405 页码:7
关键词	Polymeric membrane ion-selective electrode Polyion-sensitive electrode Polydopamine nanolayer Transmembrane ion flux Enhanced sensitivity
DOI	10.1016/j.snb.2024.135310
通讯作者	Liang, Rongning(rnliang@yic.ac.cn) ; Qin, Wei(wqin@yic.ac.cn)
英文摘要	In this work, a potentiometric polyion sensing strategy based on the surface layer-enhanced transmembrane ion transfer is demonstrated. A polydopamine (PDA) nanolayer with negative charges is modified onto the surface of the polycation-sensitive electrode membrane and used to increase the ion fluxes from the sample phase to the membrane phase. Such modification can significantly improve the detection sensitivity of potentiometric polyion sensors through electrostatic interactions between the cationic targets and anionic PDA groups, which can effectively promote the accumulation of the targets in the boundary layer of the organic membrane phase. By using a thin membrane protamine-sensitive electrode as a model, the detection sensitivity of the PDA-coated electrode (55 mV/mu g & sdot;mL-1) is nearly five times higher than that of the unmodified electrode (12 mV/ mu g & sdot;mL-1). Moreover, the proposed surface PDA-modified polyion sensor can also be utilized as a general tool for sensitive detection of other polycationic targets and polyanionic species (e.g., the new cancer biomarker cell-free DNA). The proposed potentiometric sensing platform based on surface enhancement of ion transfer offers great potential for sensitive detection of various polyionic targets.
WOS关键词	ION-SELECTIVE ELECTRODES ; ELECTROCHEMICAL SENSOR ; DETECTION LIMITS ; HEPARIN ; MODULATION ; DNA
WOS研究方向	Chemistry ; Electrochemistry ; Instruments & Instrumentation
语种	英语
WOS记录号	WOS:001170706700001
资助机构	National Natural Science Foundation of China ; Key Research Development Program of Shandong Province ; Key Deployment Project of Centre for Ocean Mega-Research of Science, Chinese Academy of Sciences ; Taishan Scholar Program of Shandong Province
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/34891]
专题	中国科学院烟台海岸带研究所
通讯作者	Liang, Rongning; Qin, Wei
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, YICCAS, Yantai 264003, Shandong, Peoples R China 2.Shandong Key Lab Coastal Environm Proc, Yantai 264003, Shandong, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Wang, Kaikai,Liang, Rongning,Qin, Wei. Enhancing the sensitivity of polymeric membrane polycation-sensitive electrodes by surface modification of a polydopamine nanolayer[J]. SENSORS AND ACTUATORS B-CHEMICAL,2024,405:7.
APA	Wang, Kaikai,Liang, Rongning,&Qin, Wei.(2024).Enhancing the sensitivity of polymeric membrane polycation-sensitive electrodes by surface modification of a polydopamine nanolayer.SENSORS AND ACTUATORS B-CHEMICAL,405,7.
MLA	Wang, Kaikai,et al."Enhancing the sensitivity of polymeric membrane polycation-sensitive electrodes by surface modification of a polydopamine nanolayer".SENSORS AND ACTUATORS B-CHEMICAL 405(2024):7.