Ratiometric fluorescent and electrochemiluminescent dual modal assay for detection of 2,6-pyridinedicarboxylic acid as an<i> anthrax</i> biomarker

doi:10.1016/j.aca.2023.342181

	Ratiometric fluorescent and electrochemiluminescent dual modal assay for detection of 2,6-pyridinedicarboxylic acid as an anthrax biomarker
	Xu, Ning 1; Li, Xin 1; Luan, Feng 1; Tian, Chunyuan 1; Zhang, Zhiyang 2; Chen, Lingxin 2; Zhuang, Xuming 1
刊名	ANALYTICA CHIMICA ACTA
	2024-02-01
卷号	1288 页码:9
关键词	6-Pyridinedicarboxylic acid Ratiometric fluorescent probe Electrochemiluminescence Metal -organic framework Bacillus anthracis
ISSN号	0003-2670
DOI	10.1016/j.aca.2023.342181
通讯作者	Chen, Lingxin(lxchen@yic.ac.cn) ; Zhuang, Xuming(xmzhuang@iccas.ac.cn)
英文摘要	2,6-pyridinedicarboxylic acid (DPA) is an excellent biomarker of Bacillus anthracis (B. anthracis). The sensitive detection of DPA, especially through visual point -of -care testing, was significant for accurate and rapid diagnosis of anthrax to timely prevent anthrax disease or biological terrorist attack. Herein, a ratiometric fluorescent (RFL) and electrochemiluminescent (ECL) dual -mode detection platform with a lanthanide ion -based metal -organic framework (Ln-MOF, i.e., M/Y-X: M = Eu, Y = Tb, and X = 4,4 ',4 ''-s-triazine-1,3,5-triyltri-m-aminobenzoic acid) was developed. Eu/Tb-TATAB nanoparticles were constructed to identify DPA. The R -FL detection platform quantitatively detected DPA by monitoring the I545/I617 ratio of the characteristic fluorescence peak intensities of Tb3+ ions and Eu3+ ions. The ECL sensing platform successfully quantified DPA by exploiting the burst effect of DPA on the ECL signal. The above methods had highly sensitive and rapid detection of DPA in water and serum samples. The results showed that this dual -mode detection platform may be projected to be a powerful instrument for preventing related biological warfare and bio-terrorism.
WOS关键词	BACTERIAL SPORE DETECTION ; BACILLUS-ANTHRACIS ; DIPICOLINIC ACID ; PROBE ; MICRORNA
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:001156258600001
资助机构	Natural Sci- ence Foundation of Shandong Province
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/34849]
专题	中国科学院烟台海岸带研究所
通讯作者	Chen, Lingxin; Zhuang, Xuming
作者单位	1.Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Xu, Ning,Li, Xin,Luan, Feng,et al. Ratiometric fluorescent and electrochemiluminescent dual modal assay for detection of 2,6-pyridinedicarboxylic acid as an anthrax biomarker[J]. ANALYTICA CHIMICA ACTA,2024,1288:9.
APA	Xu, Ning.,Li, Xin.,Luan, Feng.,Tian, Chunyuan.,Zhang, Zhiyang.,...&Zhuang, Xuming.(2024).Ratiometric fluorescent and electrochemiluminescent dual modal assay for detection of 2,6-pyridinedicarboxylic acid as an anthrax biomarker.ANALYTICA CHIMICA ACTA,1288,9.
MLA	Xu, Ning,et al."Ratiometric fluorescent and electrochemiluminescent dual modal assay for detection of 2,6-pyridinedicarboxylic acid as an anthrax biomarker".ANALYTICA CHIMICA ACTA 1288(2024):9.