Improvement of the Antioxidant and Antitumor Activities of Benzimidazole-Chitosan Quaternary Ammonium Salt on Drug Delivery Nanogels

doi:10.3390/md22010040

	Improvement of the Antioxidant and Antitumor Activities of Benzimidazole-Chitosan Quaternary Ammonium Salt on Drug Delivery Nanogels
	Ma, Bing 1,2,3; Li, Qing 1,3; Zhang, Jingjing 1,3; Mi, Yingqi 1,3; Tan, Wenqiang 1,3; Guo, Zhanyong 1,2,3
刊名	MARINE DRUGS
	2024
卷号	22 期号:1 页码:21
关键词	benzimidazole-chitosan quaternary ammonium salt acidic-responsive nanogels antioxidant activity antitumor activity
DOI	10.3390/md22010040
通讯作者	Guo, Zhanyong(zhanyongguo@hotmail.com)
英文摘要	The present study focused on the design and preparation of acid-responsive benzimidazole-chitosan quaternary ammonium salt (BIMIXHAC) nanogels for a controlled, slow-release of Doxorubicin HCl (DOX.HCl). The BIMIXHAC was crosslinked with sodium tripolyphosphate (TPP) using the ion crosslinking method. The method resulted in nanogels with low polydispersity index, small particle size, and positive zeta potential values, indicating the good stability of the nanogels. Compared to hydroxypropyl trimethyl ammonium chloride chitosan-Doxorubicin HCl-sodium tripolyphosphate (HACC-D-TPP) nanogel, the benzimidazole-chitosan quaternary ammonium salt-Doxorubicin HCl-sodium tripolyphosphate (BIMIXHAC-D-TPP) nanogel show higher drug encapsulation efficiency and loading capacity (BIMIXHAC-D-TPP 93.17 +/- 0.27% and 31.17 +/- 0.09%), with acid-responsive release profiles and accelerated release in vitro. The hydroxypropyl trimethyl ammonium chloride chitosan-sodium tripolyphosphate (HACC-TPP), and benzimidazole-chitosan quaternary ammonium salt-sodium tripolyphosphate (BIMIXHAC-TPP) nanogels demonstrated favorable antioxidant capability. The assay of cell viability, measured by the MTT assay, revealed that nanogels led to a significant reduction in the cell viability of two cancer cells: the human lung adenocarcinoma epithelial cell line (A549) and the human breast cancer cell line (MCF-7). Furthermore, the BIMIXHAC-D-TPP nanogel was 2.96 times less toxic than DOX.HCl to the mouse fibroblast cell line (L929). It was indicated that the BIMIXHAC-based nanogel with enhanced antioxidant and antitumor activities and acidic-responsive release could serve as a potential nanocarrier.
WOS关键词	DOXORUBICIN-INDUCED CARDIOTOXICITY ; BIOMEDICAL APPLICATIONS ; RESPONSIVE NANOGELS ; NANOPARTICLES ; GLUCOSE
WOS研究方向	Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:001151426300001
资助机构	The 2023 annual Special Research Assistant Project of the Chinese Academy of Sciences ; Shandong Key R&D Plan, Major Scientific and Technological Innovation ; Youth Innovation Promotion Association CAS ; Natural Science Foundation of Shandong Province of China
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/34841]
专题	中国科学院烟台海岸带研究所
通讯作者	Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Ma, Bing,Li, Qing,Zhang, Jingjing,et al. Improvement of the Antioxidant and Antitumor Activities of Benzimidazole-Chitosan Quaternary Ammonium Salt on Drug Delivery Nanogels[J]. MARINE DRUGS,2024,22(1):21.
APA	Ma, Bing,Li, Qing,Zhang, Jingjing,Mi, Yingqi,Tan, Wenqiang,&Guo, Zhanyong.(2024).Improvement of the Antioxidant and Antitumor Activities of Benzimidazole-Chitosan Quaternary Ammonium Salt on Drug Delivery Nanogels.MARINE DRUGS,22(1),21.
MLA	Ma, Bing,et al."Improvement of the Antioxidant and Antitumor Activities of Benzimidazole-Chitosan Quaternary Ammonium Salt on Drug Delivery Nanogels".MARINE DRUGS 22.1(2024):21.