Verteporfin reverses progestin resistance through YAP

	Verteporfin reverses progestin resistance through YAP
	Lina Wei 1; Xiaohong Ma 1; Yixin Hou 1; Tianyi Zhao 1; Rui Sun 1; Chunping Qiu 1; Yao Liu 1; Ziyi Qiu 1; Zhiming Liu 1; Jie Jiang 1
刊名	CELL DEATH DISCOVERY
	2023
卷号	9 期号:1
ISSN号	2058-7716
英文摘要	Progestin resistance is a problem for patients with endometrial carcinoma (EC) who require conservative treatment with progestin, and its underlying mechanisms remain unclear. YAP and TAZ (YAP/TAZ), downstream transcription coactivators of Hippo pathway, promote viability, metastasis and also drug resistance of malignant tumors. According to our microarray analysis, YAP/TAZ were upregulated in progestin resistant IshikawaPR cell versus progestin sensitive Ishikawa cell, which implied that YAP/TAZ may be a vital promotor of resistance to progestin. We found YAP/TAZ had higher expression levels among the resistant tissues than sensitive tissues. In addition, knocking down YAP/TAZ decreased cell viability, inhibited cell migration and invasion and increased the sensitivity of IshikawaPR cell to progestin. On the contrary, overexpression of YAP/TAZ increased cell proliferation, metastasis and promoted progestin resistance. We also confirmed YAP/TAZ were involved in progestin resistant process by regulating PI3K-Akt pathway. Furthermore, Verteporfin as an inhibitor of YAP/TAZ could increase sensitivity of IshikawaPR cells to progestin in vivo and in vitro. Our study for the first time indicated that YAP/TAZ play an important role in progestin resistance by regulating PI3K-Akt pathway in EC, which may provide ideas for clinical targeted therapy of progestin resistance.
语种	英语
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/34540]
专题	中国科学院烟台海岸带研究所
作者单位	1.山东大学 2.中国科学院烟台海岸带研究所
推荐引用方式 GB/T 7714	Lina Wei,Xiaohong Ma,Yixin Hou,et al. Verteporfin reverses progestin resistance through YAP[J]. CELL DEATH DISCOVERY,2023,9(1).
APA	Lina Wei.,Xiaohong Ma.,Yixin Hou.,Tianyi Zhao.,Rui Sun.,...&Jie Jiang.(2023).Verteporfin reverses progestin resistance through YAP.CELL DEATH DISCOVERY,9(1).
MLA	Lina Wei,et al."Verteporfin reverses progestin resistance through YAP".CELL DEATH DISCOVERY 9.1(2023).