Photodegradation of typical pharmaceuticals changes toxicity to algae in estuarine water: A metabolomic insight

doi:10.1016/j.scitotenv.2023.168338

CORC > 海洋研究所 > 中国科学院海洋研究所 > 海洋生态与环境科学重点实验室

	Photodegradation of typical pharmaceuticals changes toxicity to algae in estuarine water: A metabolomic insight
	Lin, Jiang 4; Chi, Lianbao 1; Yuan, Qing 3; Li, Busu 2; Feng, Mingbao 4
刊名	SCIENCE OF THE TOTAL ENVIRONMENT
	2024-01-15
卷号	908 页码:8
关键词	Pharmaceutical contamination Estuarine water Photodegradation pathways Transformation risks Metabolomics
ISSN号	0048-9697
DOI	10.1016/j.scitotenv.2023.168338
通讯作者	Li, Busu(libusu1616@163.com)
英文摘要	The ubiquitous existence of various pharmaceuticals in the marine environment has received global attention for their risk assessment. However, rather little is known thus far regarding the natural attenuation (e.g., photolysis) -induced product/mixture toxicity of these pharmaceuticals on marine organisms. In this study, the photo -degradation behavior, product formation, and risks of two representative pharmaceuticals (i.e., ciprofloxacin, CIP; diclofenac, DCF) were explored in the simulated estuary water. It was noted that both pharmaceuticals can be completely photolyzed within 1 h, and five products of CIP and three products of DCF were identified by a high-resolution liquid chromatography-mass spectrometer. Accordingly, their photodecomposition pathways were tentatively proposed. The in silico prediction suggested that the formed transformation products maintained the persistence, bioaccumulation potential, and multi-endpoint toxic effects such as genotoxicity, developmental toxicity, and acute/chronic toxicity on different aquatic species. Particularly, the non-targeted metabolomics first elucidated that DCF and its photolytic mixtures can significantly affect the antioxidant status of marine algae (Heterosigma akashiwo), triggering oxidative stress and damage to cellular components. It is very alarming that the complete photolyzed DCF sample induced more serious oxidative stress than DCF itself, which called for more concern about the photolysis-driven ecological risks. Overall, this investigation first uncoveredthe overlooked but serious toxicity of the transformation products of prevalent pharmaceuticals during natural attenuation on marine species.
资助项目	President's Research Funds from Xiamen University[20720210081]
WOS关键词	PHOTO-TRANSFORMATION PRODUCTS ; FLUOROQUINOLONE ANTIBIOTICS ; LIQUID-CHROMATOGRAPHY ; DEGRADATION KINETICS ; MARINE-ENVIRONMENT ; SALICYLIC-ACID ; BY-PRODUCTS ; DICLOFENAC ; PHOTOTRANSFORMATION ; CIPROFLOXACIN
WOS研究方向	Environmental Sciences & Ecology
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:001111535000001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/184064]
专题	海洋研究所_海洋生态与环境科学重点实验室
通讯作者	Li, Busu
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 2.Laoshan Lab, Qingdao 266237, Peoples R China 3.China United Engn Corp Ltd, Hangzhou 310052, Peoples R China 4.Xiamen Univ, Coll Environm & Ecol, Xiamen 361100, Peoples R China
推荐引用方式 GB/T 7714	Lin, Jiang,Chi, Lianbao,Yuan, Qing,et al. Photodegradation of typical pharmaceuticals changes toxicity to algae in estuarine water: A metabolomic insight[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2024,908:8.
APA	Lin, Jiang,Chi, Lianbao,Yuan, Qing,Li, Busu,&Feng, Mingbao.(2024).Photodegradation of typical pharmaceuticals changes toxicity to algae in estuarine water: A metabolomic insight.SCIENCE OF THE TOTAL ENVIRONMENT,908,8.
MLA	Lin, Jiang,et al."Photodegradation of typical pharmaceuticals changes toxicity to algae in estuarine water: A metabolomic insight".SCIENCE OF THE TOTAL ENVIRONMENT 908(2024):8.