Hypoglycemic effect of Nitraria tangutorum fruit by inhibiting glycosidase and regulating IRS1/PI3K/AKT signalling pathway and its active ingredient identification by UPLC-MS

	Hypoglycemic effect of Nitraria tangutorum fruit by inhibiting glycosidase and regulating IRS1/PI3K/AKT signalling pathway and its active ingredient identification by UPLC-MS
	Jiang, Sirong; Wang, Luya; Jia, Wenjing; Wu, Di; Wu, Li; Zhao, Xiaohui; Mei, Lijuan; Tao, Yanduo; Yue, Huilan
刊名	FOOD & FUNCTION
	2023
卷号	14 期号:17 页码:7869
英文摘要	The hypoglycemic effect of NTB-40 (40% ethanol fraction of Nitraria tangutorum fruit) in type I/II diabetic mice and its underlying mechanism and active ingredient structure were investigated. The postprandial blood glucose (PBG) lowering effect of NTB-40 treatment was confirmed by maltose, starch, and sucrose tolerance tests in alloxan-induced DM mice and sucrase and maltase inhibitory activities in vitro. More importantly, long-term dosing experiments in high-fat diet-STZ-induced diabetic mice further demonstrated that NTB-40 intervention could improve glycolipid metabolism disorder and insulin resistance (IR) by maintaining glucose homeostasis (FBG, OGTT, ITT, FINS, and HOMA-IR) and lipid homeostasis (TC, TG, HDL-C, LDL-C, and FFA), reducing inflammation (IL-6, IL-1 & beta;, and TNF-& alpha;) and oxidative stress (SOD and MDA), ameliorating the liver's histological structural abnormalities, and modulating the IRS1/PI3K/AKT signaling pathway and downstream targets (FOXO1, GSK3 & beta;, GLUT4) for decreasing hepatic gluconeogenesis and promoting glycogen synthesis and glucose uptake. All these results indicated that NTB-40 had an anti-diabetic effect by modulating the IRS1/PI3K/AKT signaling pathway and inhibiting & alpha;-glucosidase activity. Finally, the main chemical components of NTB-40, including phenolic acids, flavonoids, and alkaloids, were assigned by UPLC-Triple-TOF MS/MS.
内容类型	期刊论文
源URL	[http://210.75.249.4/handle/363003/61607]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Jiang, Sirong,Wang, Luya,Jia, Wenjing,et al. Hypoglycemic effect of Nitraria tangutorum fruit by inhibiting glycosidase and regulating IRS1/PI3K/AKT signalling pathway and its active ingredient identification by UPLC-MS[J]. FOOD & FUNCTION,2023,14(17):7869.
APA	Jiang, Sirong.,Wang, Luya.,Jia, Wenjing.,Wu, Di.,Wu, Li.,...&Yue, Huilan.(2023).Hypoglycemic effect of Nitraria tangutorum fruit by inhibiting glycosidase and regulating IRS1/PI3K/AKT signalling pathway and its active ingredient identification by UPLC-MS.FOOD & FUNCTION,14(17),7869.
MLA	Jiang, Sirong,et al."Hypoglycemic effect of Nitraria tangutorum fruit by inhibiting glycosidase and regulating IRS1/PI3K/AKT signalling pathway and its active ingredient identification by UPLC-MS".FOOD & FUNCTION 14.17(2023):7869.