A genome and single-nucleus cerebral cortex transcriptome atlas of the short-finned pilot whale Globicephala macrorhynchus | |
Kang, Hui2,3; Liu, Qun1,4,5,6; Seim, Inge7; Zhang, Wenwei8; Li, Hanbo4,5; Gao, Haiyu2,3; Lin, Wenzhi2; Lin, Mingli2; Zhang, Peijun2; Zhang, Yaolei4 | |
刊名 | MOLECULAR ECOLOGY RESOURCES |
2023-03 | |
卷号 | 23期号:5页码:1108-1123 |
关键词 | cerebral cortex cetacean cross-species analysis genome assembly Globicephala macrorhynchus single-nucleus RNA-sequencing |
ISSN号 | 1755-0998 |
通讯作者 | Fan, Guangyi ; Li, Songhai |
文献子类 | 期刊论文 |
英文摘要 | Cetaceans (dolphins, whales, and porpoises) have large and anatomically sophisticated brains. To expand our understanding of the cellular makeup of cetacean brains and the similarities and divergence between the brains of cetaceans and terrestrial mammals, we report a short-finned pilot whale (Globicephala macrorhynchus) single-nucleus transcriptome atlas. To achieve this goal, we assembled a chromosome-scale reference genome spanning 2.25 Gb on 22 chromosomes and profiled the gene expression of five major anatomical cortical regions of the short-finned pilot whale by single-nucleus RNA-sequencing (snRNA-seq). We identified six major cell lineages in the cerebral cortex (excitatory neurons, inhibitory neurons, oligodendrocytes, oligodendrocyte precursor cells, astrocytes, and endothelial cells), eight molecularly distinct subclusters of excitatory neurons, and four subclusters of inhibitory neurons. Finally, a comparison of snRNA-seq data from the short-finned pilot whale, human, and rhesus macaque revealed a broadly conserved cellular makeup of brain cell types. Our study provides genomic resources and molecular insights into cetacean brain evolution. |
WOS研究方向 | Biochemistry & Molecular Biology ; Environmental Sciences & Ecology ; Evolutionary Biology |
语种 | 英语 |
WOS记录号 | WOS:000945746300001 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://ir.idsse.ac.cn/handle/183446/10150] |
专题 | 深海科学研究部_深海生物学研究室_海洋哺乳动物与海洋生物声学研究组 |
通讯作者 | Fan, Guangyi; Li, Songhai |
作者单位 | 1.Univ Copenhagen, Dept Biol, Copenhagen, Denmark; 2.Chinese Acad Sci, Marine Mammal & Marine Bioacoust Lab, Inst Deep Sea Sci & Engn, Sanya, Peoples R China; 3.Univ Chinese Acad Sci, Beijing, Peoples R China; 4.BGI Shenzhen, BGI Qingdao, Qingdao, Peoples R China; 5.BGI Qingdao, Lars Bolund Inst Regenerat Med, Qingdao Europe Adv Inst Life Sci, Qingdao, Peoples R China; 6.BGI Qingdao, Qingdao Key Lab Marine Genom, Qingdao, Peoples R China; 7.Nanjing Normal Univ, Coll Life Sci, Integrat Biol Lab, Nanjing, Peoples R China; 8.BGI Shenzhen, State Key Lab Agr Genom, Shenzhen, Peoples R China; |
推荐引用方式 GB/T 7714 | Kang, Hui,Liu, Qun,Seim, Inge,et al. A genome and single-nucleus cerebral cortex transcriptome atlas of the short-finned pilot whale Globicephala macrorhynchus[J]. MOLECULAR ECOLOGY RESOURCES,2023,23(5):1108-1123. |
APA | Kang, Hui.,Liu, Qun.,Seim, Inge.,Zhang, Wenwei.,Li, Hanbo.,...&Li, Songhai.(2023).A genome and single-nucleus cerebral cortex transcriptome atlas of the short-finned pilot whale Globicephala macrorhynchus.MOLECULAR ECOLOGY RESOURCES,23(5),1108-1123. |
MLA | Kang, Hui,et al."A genome and single-nucleus cerebral cortex transcriptome atlas of the short-finned pilot whale Globicephala macrorhynchus".MOLECULAR ECOLOGY RESOURCES 23.5(2023):1108-1123. |
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