Porphyra haitanensis Polysaccharides Attenuates Blood Lipid via Gut-Liver Axis in Diet-Induced High-Fat Mesocricetus auratus through Multiple Integrated Omics

doi:10.1002/mnfr.202200638

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	Porphyra haitanensis Polysaccharides Attenuates Blood Lipid via Gut-Liver Axis in Diet-Induced High-Fat Mesocricetus auratus through Multiple Integrated Omics
	Zeng, Hongliang 2,3,4; Chen, Peilin 3,4; Wang, Zhiyun 3,4; Hu, Xiaoke 1; Zhang, Yi 2,3,4; Zheng, Baodong 2,3,4
刊名	MOLECULAR NUTRITION & FOOD RESEARCH
	2023-01-26
页码	15
关键词	gut microbiota gut-liver axis hyperlipidemia lipomics Porphyra haitanensis polysaccharide transcriptomics
ISSN号	1613-4125
DOI	10.1002/mnfr.202200638
通讯作者	Zhang, Yi(zyifst@fafu.edu.cn) ; Zheng, Baodong(zbdfst@fafu.edu.cn)
英文摘要	ScopeHyperlipidemia is currently a global public health problem severely affecting people's physical and mental health, as well as their quality of life. Methods and resultsThe present study is aimed at revealing the mechanism of Porphyra haitanensis polysaccharide (PHP) in decreasing blood lipids by acting through gut-liver axis in Mesocricetus auratus fed a high-fat diet. PHP significantly prevented increases in serum total cholesterol, triglycerides and low-density lipoprotein cholesterol, and alleviated damage to liver cells induced by a high-fat diet M. auratus, in a dose-dependent manner. PHP promotes proliferation of Muribaculaceae and Faecalibaculum, thereby enhancing the production of butyric acid both in the colon and liver, particularly high-dose PHP (HPHP). Low-dose PHP (LPHP) promotes the expression of phosphatidylcholine metabolites and fatty acid transport genes, and inhibits the expression of genes involved in fat degradation (Abhd5), adipogenesis (Me1), fatty acid synthesis (Fasn and Pnpla3), and fatty acid chain elongation (Elovl6) in the liver. However, HPHP inhibits the expression of triglyceride metabolites and promotes the expression of fatty acid transporter (CD36), fatty acid oxidation (Acacb), and peroxisome proliferator-activated receptor gamma (PPARg) genes in the liver. ConclusionPHP regulates lipid metabolism through the gut microbiota, and the gut-liver axis plays an important role in its hypolipidemic effects.
WOS关键词	LIPOPROTEIN-LIPASE ; IN-VITRO ; SULFATED POLYSACCHARIDE ; HEPATIC STEATOSIS ; ADIPOSE-TISSUE ; PPAR-GAMMA ; MICROBIOTA ; OBESITY ; VIVO ; ANTIOXIDANT
WOS研究方向	Food Science & Technology
语种	英语
WOS记录号	WOS:000918971400001
资助机构	Program for Leading Talent in Fujian Provincial University
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/32083]
专题	海岸带生物学与生物资源利用重点实验室
通讯作者	Zhang, Yi; Zheng, Baodong
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Fujian Agr & Forestry Univ, Fujian Prov Key Lab Qual Sci & Proc Technol Specia, Fuzhou 350002, Peoples R China 3.Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Fujian, Peoples R China 4.Minist Educ, Engn Res Ctr Fujian Taiwan Special Marine Food Pro, Fuzhou 350002, Fujian, Peoples R China
推荐引用方式 GB/T 7714	Zeng, Hongliang,Chen, Peilin,Wang, Zhiyun,et al. Porphyra haitanensis Polysaccharides Attenuates Blood Lipid via Gut-Liver Axis in Diet-Induced High-Fat Mesocricetus auratus through Multiple Integrated Omics[J]. MOLECULAR NUTRITION & FOOD RESEARCH,2023:15.
APA	Zeng, Hongliang,Chen, Peilin,Wang, Zhiyun,Hu, Xiaoke,Zhang, Yi,&Zheng, Baodong.(2023).Porphyra haitanensis Polysaccharides Attenuates Blood Lipid via Gut-Liver Axis in Diet-Induced High-Fat Mesocricetus auratus through Multiple Integrated Omics.MOLECULAR NUTRITION & FOOD RESEARCH,15.
MLA	Zeng, Hongliang,et al."Porphyra haitanensis Polysaccharides Attenuates Blood Lipid via Gut-Liver Axis in Diet-Induced High-Fat Mesocricetus auratus through Multiple Integrated Omics".MOLECULAR NUTRITION & FOOD RESEARCH (2023):15.