MoS2/LaF3 for enhanced photothermal therapy performance of poorly-differentiated hepatoma

doi:10.1016/j.colsurfb.2022.112462

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	MoS2/LaF3 for enhanced photothermal therapy performance of poorly-differentiated hepatoma
	L. Sun; H. F. Bai; H. J. Jiang; P. Zhang; J. Li; W. D. Qiao; D. Wang; G. S. Liu and X. L. Wang
刊名	Colloids and Surfaces B-Biointerfaces
	2022
卷号	214 页码:8
ISSN号	0927-7765
DOI	10.1016/j.colsurfb.2022.112462
英文摘要	Photothermal therapy (PTT) based on nanoparticle had been widely used to antitumor treatment. However, low photothermal conversion efficiency (PCE) is the main hurdle for antitumor treatment. To improve the PCE and gain ideal clinical the nanoparticle with higher photothermal conversion efficiency, we have developed a highly efficient solar absorber with MoS2/LaF3/ polydimethylsiloxane(PDMS) which can enhance the absorption of solar irradiation engergy, however, its photothermal effect irradiated by near-infrared light has not yet been investigated. The knowledge absence in photothermal effect will impede MoS2/LaF3/PDMS to be used for cancer therapy in clinic. In this study, we applied LaF3-loaded, MoS2-based photothermal conversion agents (PTAs) for improved photothermal cancer therapy. The study showed that the MoS2/LaF3 nanoflowers showed higher photothermal conversion efficiency (PCE, 42.5%) and could more effectively inhibit cancer cell proliferation compared to MoS2-based PTT agents in vitro. In vivo, the results further revealed that photothermal therapy using MoS2/LaF3 nanoflowers could significantly inhibit solid tumor growth. The study clearly demonstrated that MoS2/LaF3 could work at under low power NIR Laser in vitro and in vivo, resulting in a very impressive therapeutic effect in tumor-bearing mice. The MoS2/LaF3 nanoflowers will be prominent candidate nanoparticle for effective inhibiting tumor growth by photothermal therapy.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.ciomp.ac.cn/handle/181722/66861]
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	L. Sun,H. F. Bai,H. J. Jiang,et al. MoS2/LaF3 for enhanced photothermal therapy performance of poorly-differentiated hepatoma[J]. Colloids and Surfaces B-Biointerfaces,2022,214:8.
APA	L. Sun.,H. F. Bai.,H. J. Jiang.,P. Zhang.,J. Li.,...&G. S. Liu and X. L. Wang.(2022).MoS2/LaF3 for enhanced photothermal therapy performance of poorly-differentiated hepatoma.Colloids and Surfaces B-Biointerfaces,214,8.
MLA	L. Sun,et al."MoS2/LaF3 for enhanced photothermal therapy performance of poorly-differentiated hepatoma".Colloids and Surfaces B-Biointerfaces 214(2022):8.