The Complex of Phycobiliproteins, Fucoxanthin, and Krill Oil Ameliorates Obesity through Modulation of Lipid Metabolism and Antioxidants in Obese Rats

doi:10.3390/nu14224815

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	The Complex of Phycobiliproteins, Fucoxanthin, and Krill Oil Ameliorates Obesity through Modulation of Lipid Metabolism and Antioxidants in Obese Rats
	Qiang, Xi 1,2,3; Guo, Chuanlong 4; Gu, Wenhui 1,5; Song, Yuling 1; Zhang, Yuhong 6; Gong, Xiangzhong 2; Wang, Lijun 1,3,5; Wang, Guangce 1,5
刊名	NUTRIENTS
	2022-11-01
卷号	14 期号:22 页码:12
关键词	obesity lipid metabolism phycobiliproteins fucoxanthin krill oil
DOI	10.3390/nu14224815
通讯作者	Wang, Lijun(wanglijun@qdio.ac.cn) ; Wang, Guangce(gcwang@qdio.ac.cn)
英文摘要	Phycobiliproteins, fucoxanthin, and krill oil are natural marine products with excellent activities. In the study, we prepared the complex of phycobiliproteins, fucoxanthin, and krill oil (PFK) and assessed the anti-obesity, lipid-lowering, and antioxidant activities in high-fat diet rats. The results showed that the rats significantly and safely reduced body weight gain and regulated serum biochemical parameters at 50 mg/kg phycobiliproteins, 10 mg/kg fucoxanthin, and 100 mg/kg krill oil. Furthermore, the molecular mechanism study suggested that the complex of PFK confined the enzyme activities of lipid synthesis and enhanced antioxidant activity to improve obesity indirectly. The conclusions demonstrated that the complex of PFK has potent anti-obesity and hypolipidemic effects which have potential use as a natural and healthy food and medicine for anti-obesity and lowering blood lipids in the future.
资助项目	Major Scientific and Technological Innovation Projects of Shandong Province[2019JZZY010815] ; National Key R&D Program of China[2018YFD0901500] ; Ministry of Agriculture and Rural Affairs of the People's Republic of China[CARS-50] ; Nantong Municipal Science and Technology Planning Project[MS22021017] ; Research Fund for the Taishan Scholar Project of Shandong Province[tspd 20210316]
WOS研究方向	Nutrition & Dietetics
语种	英语
出版者	MDPI
WOS记录号	WOS:000887567700001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/180268]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Wang, Lijun; Wang, Guangce
作者单位	1.Chinese Acad Sci, Ctr Ocean Megasci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Ocean Univ China, Coll Marine Life Sci, Qingdao 266003, Peoples R China 3.Nantong Zhong Ke Marine Sci & Technol R&D Ctr, Nantong 226334, Peoples R China 4.Qingdao Univ Sci & Technol, Coll Chem Engn, Dept Pharm, Qingdao 266042, Peoples R China 5.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 6.Qingdao Shinan Dist Ctr Dis Control & Prevent, Qingdao 266072, Peoples R China
推荐引用方式 GB/T 7714	Qiang, Xi,Guo, Chuanlong,Gu, Wenhui,et al. The Complex of Phycobiliproteins, Fucoxanthin, and Krill Oil Ameliorates Obesity through Modulation of Lipid Metabolism and Antioxidants in Obese Rats[J]. NUTRIENTS,2022,14(22):12.
APA	Qiang, Xi.,Guo, Chuanlong.,Gu, Wenhui.,Song, Yuling.,Zhang, Yuhong.,...&Wang, Guangce.(2022).The Complex of Phycobiliproteins, Fucoxanthin, and Krill Oil Ameliorates Obesity through Modulation of Lipid Metabolism and Antioxidants in Obese Rats.NUTRIENTS,14(22),12.
MLA	Qiang, Xi,et al."The Complex of Phycobiliproteins, Fucoxanthin, and Krill Oil Ameliorates Obesity through Modulation of Lipid Metabolism and Antioxidants in Obese Rats".NUTRIENTS 14.22(2022):12.