Glucose Oxidase-Integrated Metal-Polyphenolic Network as a Microenvironment-Activated Cascade Nanozyme for Hyperglycemic Wound Disinfection

	Glucose Oxidase-Integrated Metal-Polyphenolic Network as a Microenvironment-Activated Cascade Nanozyme for Hyperglycemic Wound Disinfection
	Shi, S; Zhang, QP; Sun, H; Su, ZH; Dan, J; Liang, YM; Kang, Y; Du, T; Sun, J; Wang, JL
刊名	ACS BIOMATERIALS SCIENCE & ENGINEERING
	2022
英文摘要	The high systemic blood glucose concentration of hyperglycemic wound microenvironment (WME) severely impedes the disinfection and healing of infected skin wounds. Herein, a WME-activated smart natural product, integrated GOx-GA-Fe nanozyme (GGFzyme), is engineered, which combines a nanozyme and natural enzyme to promote reactive oxygen species (ROS) generation in situ for hyperglycemic wound disinfection. GGFzyme can consume a high concentration of glucose in hyperglycemia wounds and generate H2O2. The conversion of glucose into gluconic acid not avails starvation treatment but reduces the pH of WME to elevate the catalytic activities of both the nanozyme (GA- Fe) and natural enzyme (GOx). And H2O2 is then high efficiently catalyzed into center dot OH and O2 center dot- in situ to combat pathogenic bacteria and promote wound disinfection. The high catalytic antibacterial capacity and superior biosafety, combined with beneficial WME modulation, demonstrate that GGFzyme is a promising therapeutic agent for hyperglycemic wounds.
内容类型	期刊论文
源URL	[http://210.75.249.4/handle/363003/61056]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Shi, S,Zhang, QP,Sun, H,et al. Glucose Oxidase-Integrated Metal-Polyphenolic Network as a Microenvironment-Activated Cascade Nanozyme for Hyperglycemic Wound Disinfection[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2022.
APA	Shi, S.,Zhang, QP.,Sun, H.,Su, ZH.,Dan, J.,...&Zhang, WT.(2022).Glucose Oxidase-Integrated Metal-Polyphenolic Network as a Microenvironment-Activated Cascade Nanozyme for Hyperglycemic Wound Disinfection.ACS BIOMATERIALS SCIENCE & ENGINEERING.
MLA	Shi, S,et al."Glucose Oxidase-Integrated Metal-Polyphenolic Network as a Microenvironment-Activated Cascade Nanozyme for Hyperglycemic Wound Disinfection".ACS BIOMATERIALS SCIENCE & ENGINEERING (2022).