A New Method for Characterization of Single Cell Using System Identification

CORC > 沈阳自动化研究所 > 中国科学院沈阳自动化研究所 > 机器人学研究室

	A New Method for Characterization of Single Cell Using System Identification
	Ma S(马爽)2,3,4; Wang WX(王文学)2,3; Wang YC(王越超)2,3; Liu LQ(刘连庆)2,3; Wang TL(王天路)1
	2021
会议日期	April 25-29, 2021
会议地点	Xiamen, China
关键词	single cell dynamic mechanical properly Atomic Force Microscopy system identification
页码	832-837
英文摘要	The mechanical properties of cells reflect the state of macro-organism. While many approaches are available for performing mechanical property investigations on cells, to characterize dynamic mechanical property of a single cell is challenging. We measure the mechanical properties of a single cell using an Atomic Force Microscopy and develop a novel method to characterize dynamic mechanical property of a single cell based on the theory of system identification. We evaluated the new method by comparing its performance with the other methods in classifying different kinds of cells. The results show that the method we proposed outperformed other methods by achieving average classification accuracy of more than 90%. This work provides a new attempt for characterization of a single cell system, which is of great significance for studying the dynamic changes of the mechanical properties of single cells and analyzing or controlling the state of cells.
源文献作者	IEEE, IEEE Nanotechnol Council, Peking Univ, Univ Amoiensis, UESTC, ICANX
产权排序	1
会议录	Proceedings of the 16th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2021
会议录出版者	IEEE
会议录出版地	New York
语种	英语
ISSN号	2474-3747
ISBN号	978-0-7381-2429-2
WOS记录号	WOS:000693407600097
内容类型	会议论文
源URL	[http://ir.sia.cn/handle/173321/29656]
专题	沈阳自动化研究所_机器人学研究室
通讯作者	Wang WX(王文学); Liu LQ(刘连庆)
作者单位	1.Department of Radiopherapy, Cancer Hospital of China. Medical University, Liaoning Cancer Hospital and Institute, Shenyang, China 2.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China 3.Institutes for Robotics and Intelligent Manufacturing, Chinese Academy of Sciences, Shenyang, China 4.University of Chinese Academy of Sciences, Beijing, China
推荐引用方式 GB/T 7714	Ma S,Wang WX,Wang YC,et al. A New Method for Characterization of Single Cell Using System Identification[C]. 见:. Xiamen, China. April 25-29, 2021.