Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing alpha-synuclein and immune activation of Parkinson's disease

doi:10.1126/sciadv.aba3967

	Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing alpha-synuclein and immune activation of Parkinson's disease
	Liu, Linying 1,2,3; Li, Yan 1,2; Peng, Huan 1,2; Liu, Ruiyuan 1,2; Ji, Weihong 1,2; Shi, Zhuyan 1,2; Shen, Jie 1,2; Ma, Guanghui 1; Zhang, Xin 1,2
刊名	SCIENCE ADVANCES
	2020-12-01
卷号	6 期号:50 页码:11
ISSN号	2375-2548
DOI	10.1126/sciadv.aba3967
英文摘要	The most critical problem in the treatment of neurodegenerative diseases is brain neuronal protection, which can be overcome by clearing pathological substances and regulating the immune environment. In the above treatment strategies, the traditional poor drug delivery problem is inevitable. Here, we show an engineering core-shell hybrid system named rabies virus glycoprotein (RVG) peptide-modified exosome (EXO) curcumin/phenylboronic acid-poly(2-(dimethylamino)ethyl acrylate) nanoparticle/small interfering RNA targeting SNCA (REXO-C/ANP/S). It is a nanoscavenger for clearing alpha-synuclein aggregates and reducing their cytotoxicity in Parkinson's disease neurons. The motor behavior of Parkinson's disease mice is substantially improved after REXO-C/ANP/S treatment. In particular, we demonstrate that REXO-C/ANP/S is also a nanoscavenger for clearing immune activation due to its natural immature dendritic cell EXO coating. Our findings show that REXO-C/ANP/S may serve as a platform for neurodegenerative diseases treatment.
资助项目	Beijing Nova Program[Z201100006820140] ; National High Technology Research and Development Program[2016YFA0200303] ; National Natural Science Foundation of China[21905283] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; Beijing Natural Science Foundation[2192057] ; Beijing Natural Science Foundation[L172046]
WOS关键词	DENDRITIC CELLS ; SIRNA DELIVERY ; MOTOR DYSFUNCTION ; CURCUMIN ; BRAIN ; AGGREGATION ; INDUCTION ; IL-10
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	AMER ASSOC ADVANCEMENT SCIENCE
WOS记录号	WOS:000599903600002
资助机构	Beijing Nova Program ; National High Technology Research and Development Program ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/42840]
专题	中国科学院过程工程研究所
通讯作者	Zhang, Xin
作者单位	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Beijing Polytech, Coll Bioengn, Beijing 100176, Peoples R China
推荐引用方式 GB/T 7714	Liu, Linying,Li, Yan,Peng, Huan,et al. Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing alpha-synuclein and immune activation of Parkinson's disease[J]. SCIENCE ADVANCES,2020,6(50):11.
APA	Liu, Linying.,Li, Yan.,Peng, Huan.,Liu, Ruiyuan.,Ji, Weihong.,...&Zhang, Xin.(2020).Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing alpha-synuclein and immune activation of Parkinson's disease.SCIENCE ADVANCES,6(50),11.
MLA	Liu, Linying,et al."Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing alpha-synuclein and immune activation of Parkinson's disease".SCIENCE ADVANCES 6.50(2020):11.