Sequential drug release via chemical diffusion and physical barriers enabled by hollow multishelled structures

doi:10.1038/s41467-020-18177-2

	Sequential drug release via chemical diffusion and physical barriers enabled by hollow multishelled structures
	Zhao, Decai 2,3; Yang, Nailiang 2,3; Wei, Yan 4; Jin, Quan 2; Wang, Yanlei 5; He, Hongyan 5; Yang, Yang 6; Han, Bing 1,7; Zhang, Suojiang 5; Wang, Dan 2,3
刊名	NATURE COMMUNICATIONS
	2020-09-07
卷号	11 期号:1 页码:7
ISSN号	2041-1723
DOI	10.1038/s41467-020-18177-2
英文摘要	Hollow multishelled structures (HoMSs), with relatively isolated cavities and hierarchal pores in the shells, are structurally similar to cells. Functionally inspired by the different transmission forms in living cells, we studied the mass transport process in HoMSs in detail. In the present work, after introducing the antibacterial agent methylisothiazolinone (MIT) as model molecules into HoMSs, we discover three sequential release stages, i.e., burst release, sustained release and stimulus-responsive release, in one system. The triple-shelled structure can provide a long sterility period in a bacteria-rich environment that is nearly 8 times longer than that of the pure antimicrobial agent under the same conditions. More importantly, the HoMS system provides a smart responsive release mechanism that can be triggered by environmental changes. All these advantages could be attributed to chemical diffusion- and physical barrier-driven temporally-spatially ordered drug release, providing a route for the design of intelligent nanomaterials.
资助项目	National Natural Science Foundation of China[21822005] ; National Natural Science Foundation of China[21820102002] ; National Natural Science Foundation of China[51672276] ; National Natural Science Foundation of China[51922077] ; National Natural Science Foundation of China[81922019] ; National Natural Science Foundation of China[21890762] ; National Natural Science Foundation of China[51972005] ; National Key R&D Program of China[2016YFB0600903] ; Youth Innovation Promotion Association of CAS[2017070]
WOS关键词	SILICA NANOPARTICLES ; ANTIBACTERIAL ; MICROSPHERES ; NANOSPHERES ; SPHERES
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE RESEARCH
WOS记录号	WOS:000573247600009
资助机构	National Natural Science Foundation of China ; National Key R&D Program of China ; Youth Innovation Promotion Association of CAS
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/42305]
专题	中国科学院过程工程研究所
通讯作者	Zhang, Suojiang; Wang, Dan
作者单位	1.Peking Univ, Natl Engn Lab Digital & Mat Technol Stomatol, Sch & Hosp Stomatol, Dept Orthodont, 22 Zhongguancun South Ave, Beijing 100081, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 Beiertiao, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Peking Univ, Natl Engn Lab Digital & Mat Technol Stomatol, Beijing Lab Biomed Mat, Sch & Hosp Stomatol,Dept Geriatr Dent,NMPA Key La, Beijing 100081, Peoples R China 5.Chinese Acad Sci, Key Lab Green Proc & Engn, Inst Proc Engn, 1 Beiertiao, Beijing 100190, Peoples R China 6.Tongji Univ, Inst Adv Study, Shanghai Pulm Hosp, Dept Thorac Surg, Shanghai 200430, Peoples R China 7.Peking Univ, Beijing Key Lab Digital Stomatol, 22 Zhongguancun South Ave, Beijing 100081, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Decai,Yang, Nailiang,Wei, Yan,et al. Sequential drug release via chemical diffusion and physical barriers enabled by hollow multishelled structures[J]. NATURE COMMUNICATIONS,2020,11(1):7.
APA	Zhao, Decai.,Yang, Nailiang.,Wei, Yan.,Jin, Quan.,Wang, Yanlei.,...&Wang, Dan.(2020).Sequential drug release via chemical diffusion and physical barriers enabled by hollow multishelled structures.NATURE COMMUNICATIONS,11(1),7.
MLA	Zhao, Decai,et al."Sequential drug release via chemical diffusion and physical barriers enabled by hollow multishelled structures".NATURE COMMUNICATIONS 11.1(2020):7.