Xishaglaucumins A-J, New Cembranoids with Anti-Inflammatory Activities from the South China Sea Soft Coral Sarcophyton glaucum

doi:10.1002/cjoc.202100564

	Xishaglaucumins A-J, New Cembranoids with Anti-Inflammatory Activities from the South China Sea Soft Coral Sarcophyton glaucum
	Li, Jin-Feng 1,2,3; Zeng, Yan-Bo 1,3; Li, Wang-Sheng 2,4; Luo, Hui 4; Zhang, Hai-Yan 2; Guo, Yue-Wei 2,5
刊名	CHINESE JOURNAL OF CHEMISTRY
	2022
卷号	40 期号:1 页码:79-90
关键词	Sarcophyton glaucum Cembranoids Configuration determination X-ray diffraction NMR spectroscopy
ISSN号	1001-604X
DOI	10.1002/cjoc.202100564
通讯作者	Zeng, Yan-Bo(zengyanbo@itbb.org.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要	Ten new cembrane-type diterpenoids, namely xishaglaucumins A-J (1-10), along with ten known related ones (11-20), have been isolated from the soft coral Sarcophyton glaucum collected off the Xisha Island in the South China Sea. Their structures were elucidated by extensive spectroscopic analysis, quantum mechanical nuclear magnetic resonance (QM-NMR) methods, X-ray diffraction analysis, chemical methods and comparison with the reported data in the literature. The absolute configuration of new compounds 1, 5 and known compounds 11, 12, 16 and 20 were determined either by chemical methods or by X-ray diffraction analysis using Cu K alpha (lambda = 1.5417 angstrom). In in vitro bioassay, compound 4 exhibited inhibitory effects on lipopolysaccharide (LPS)-induced inflammatory responses in BV-2 microglial cells. [GRAPHICS]
资助项目	National Natural Science Foundation of China[81991521] ; National Natural Science Foundation of China[41776093] ; National Key Research and Development Program of China[2018YFC0310903] ; Key Research and Development Project of Hainan Province[ZDYF2021SHFZ107] ; Financial Fund of the Ministry of Agriculture and Rural Affairs, P. R. China[NFZX2021] ; SKLDR/SIMM Project[SIMM2103ZZ-06]
WOS关键词	ANTI-TUMOR-PROMOTER ; MARINE TERPENES ; METABOLITES ; DITERPENES ; CHEMISTRY
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000722182500001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/299039]
专题	中国科学院上海药物研究所
通讯作者	Zeng, Yan-Bo; Guo, Yue-Wei
作者单位	1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Prov Key Lab Funct Components Res & Utiliz, Haikou 571101, Hainan, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 3.Hebei Agr Univ, Ocean Coll, Qinhuangdao 066000, Hebei, Peoples R China 4.Guangdong Med Univ, Marine Biomed Res Inst, Key Lab Zhanjiang Res & Dev Marine Microbial Reso, Zhanjiang 524023, Guangdong, Peoples R China 5.Bohai Rim Adv Res Inst Drug Discovery, Yantai 264000, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Li, Jin-Feng,Zeng, Yan-Bo,Li, Wang-Sheng,et al. Xishaglaucumins A-J, New Cembranoids with Anti-Inflammatory Activities from the South China Sea Soft Coral Sarcophyton glaucum[J]. CHINESE JOURNAL OF CHEMISTRY,2022,40(1):79-90.
APA	Li, Jin-Feng,Zeng, Yan-Bo,Li, Wang-Sheng,Luo, Hui,Zhang, Hai-Yan,&Guo, Yue-Wei.(2022).Xishaglaucumins A-J, New Cembranoids with Anti-Inflammatory Activities from the South China Sea Soft Coral Sarcophyton glaucum.CHINESE JOURNAL OF CHEMISTRY,40(1),79-90.
MLA	Li, Jin-Feng,et al."Xishaglaucumins A-J, New Cembranoids with Anti-Inflammatory Activities from the South China Sea Soft Coral Sarcophyton glaucum".CHINESE JOURNAL OF CHEMISTRY 40.1(2022):79-90.