Macroporous and Antibacterial Hydrogels Enabled by Incorporation of Mg-Cu Alloy Particles for Accelerating Skin Wound Healing

doi:10.1007/s40195-021-01335-w

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	Macroporous and Antibacterial Hydrogels Enabled by Incorporation of Mg-Cu Alloy Particles for Accelerating Skin Wound Healing
	Yin, Jiewei 1; Xu, Pengcheng 2; Wu, Kang 1; Zhou, Huan 3; Lin, Xiao 1; Tan, Lili 4; Yang, Huilin 2; Yang, Ke 4; Yang, Lei 1,3
刊名	ACTA METALLURGICA SINICA-ENGLISH LETTERS
	2021-11-18
页码	14
关键词	Mg-Cu alloy Wound repair Macroporous Hydrogel Bacterial inhibition
ISSN号	1006-7191
DOI	10.1007/s40195-021-01335-w
通讯作者	Lin, Xiao(xlin@suda.edu.cn) ; Yang, Ke(kyang@imr.ac.cn) ; Yang, Lei(ylei@hebut.edu.cn)
英文摘要	Repair of severe skin tissue injury remains a great challenge and wound infection is still a formidable problem. In this study, new macroporous and antibacterial gelatin/alginate (SAG)-based hydrogels for wound repair were designed and developed based on in-situ gas foaming method and ion release strategy as a result of Mg-Cu particles degradation in the hydrogel matrix. The addition of Mg-Cu particles decreased the storage modulus of SAG, maintained its mechanical resilience and enhanced its water-absorbing capability. Moreover, the water vapor transmission rate of SAG added with 2 wt.% Mg-Cu (SAG-2MC) was 124% of that of medical gauze and 804% of commercial Tegaderm (TM) film dressing. The bacterial inhibition rates of SAG-2MC against S. aureus, E. coli and P. aeruginosa reached 99.9% +/- 0.1%, 98.7% +/- 1.2% and 98.0% +/- 0.7%, respectively, significantly greater than those of the SAG hydrogel and Mg particle-modified hydrogels. In addition, SAG-2MC hydrogel was biocompatible and promoted cell migration. In vivo experiment results indicated that SAG-2MC significantly accelerated the skin wound healing in murine model as demonstrated by higher epidermis thickness, more collagen deposition and enhanced angiogenesis compared with SAG-0MC, SAG-2M and Tegaderm (TM) film. In summary, Mg-Cu particles have great potential to modulate the physiochemical and biological properties of SAG hydrogels. Mg-Cu particle-modified SAG hydrogels reveal significant promise in the treatment of severe skin wound or other soft tissue lesions.
资助项目	National Natural Science Foundation of China[82025025] ; National Natural Science Foundation of China[51672184] ; National Natural Science Foundation of China[31801585] ; National Natural Science Foundation of China[81622032] ; National Natural Science Foundation of China[32171321] ; National Key Research and Development Program of China[2020YFC1107401] ; Suzhou Science and Technology Project[SYS2019022] ; China Postdoctoral Science Foundation[2020T130459] ; Priority Academic Program Development of Jiangsu High Education Institutions (PAPD)
WOS研究方向	Metallurgy & Metallurgical Engineering
语种	英语
出版者	CHINESE ACAD SCIENCES, INST METAL RESEARCH
WOS记录号	WOS:000720204500001
资助机构	National Natural Science Foundation of China ; National Key Research and Development Program of China ; Suzhou Science and Technology Project ; China Postdoctoral Science Foundation ; Priority Academic Program Development of Jiangsu High Education Institutions (PAPD)
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/167484]
专题	金属研究所_中国科学院金属研究所
通讯作者	Lin, Xiao; Yang, Ke; Yang, Lei
作者单位	1.Soochow Univ, Coll Chem Chem Engn & Mat Sci, Orthoped Inst, Suzhou 215006, Peoples R China 2.Soochow Univ, Affiliated Hosp 1, Dept Orthopaed, Suzhou 215006, Peoples R China 3.Hebei Univ Technol, Ctr Hlth Sci & Engn CHSE, Sch Hlth Sci & Biomed Engn, Tianjin 300130, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Yin, Jiewei,Xu, Pengcheng,Wu, Kang,et al. Macroporous and Antibacterial Hydrogels Enabled by Incorporation of Mg-Cu Alloy Particles for Accelerating Skin Wound Healing[J]. ACTA METALLURGICA SINICA-ENGLISH LETTERS,2021:14.
APA	Yin, Jiewei.,Xu, Pengcheng.,Wu, Kang.,Zhou, Huan.,Lin, Xiao.,...&Yang, Lei.(2021).Macroporous and Antibacterial Hydrogels Enabled by Incorporation of Mg-Cu Alloy Particles for Accelerating Skin Wound Healing.ACTA METALLURGICA SINICA-ENGLISH LETTERS,14.
MLA	Yin, Jiewei,et al."Macroporous and Antibacterial Hydrogels Enabled by Incorporation of Mg-Cu Alloy Particles for Accelerating Skin Wound Healing".ACTA METALLURGICA SINICA-ENGLISH LETTERS (2021):14.