RNA-binding protein 39: a promising therapeutic target for cancer

doi:10.1038/s41420-021-00598-7

	RNA-binding protein 39: a promising therapeutic target for cancer
	Xu, Caipeng 1,2,3,7; Chen, Xiaohua 1,2,3,7; Zhang, Xuetian 1,2,3,7; Zhao, Dapeng 1,2,3,7; Dou, Zhihui 1,2,3,7; Xie, Xiaodong 6; Li, Hongyan 1,2,3,7; Yang, Hongying 5; Li, Qiang 1,2,3,4,7; Zhang, Hong 1,2,3,4,7
刊名	CELL DEATH DISCOVERY
	2021-08-13
卷号	7 期号:1 页码:9
DOI	10.1038/s41420-021-00598-7
通讯作者	Li, Qiang(liq@impcas.ac.cn) ; Zhang, Hong(zhang.h@impcas.ac.cn) ; Di, Cuixia(dicx@impcas.ac.cn)
英文摘要	RNA-binding motif protein 39 (RBM39), as a key factor in tumor-targeted mRNA and protein expression, not only plays a vital role in tumorigenesis, but also has broad development prospects in clinical treatment and drug research. Moreover, since RBM39 was identified as a target of sulfonamides, it has played a key role in the emerging field of molecule drug development. Hence, it is of great significance to study the interaction between RBM39 and tumors and the clinical application of drug-targeted therapy. In this paper, we describe the possible multi-level regulation of RBM39, including gene transcription, protein translation, and alternative splicing. Importantly, the molecular function of RBM39 as an important splicing factor in most common tumors is systematically outlined. Furthermore, we briefly introduce RBM39's tumor-targeted drug research and its clinical application, hoping to give reference significance for the molecular mechanism of RBM39 in tumors, and provide reliable ideas for in-depth research for future therapeutic strategies.
资助项目	National Key R&D project of the Chinese Ministry of Science and Technology[2018YFE0205100] ; Key Program of the National Natural Science Foundation of China[U1632270] ; National Natural Science Foundation of China[11675234]
WOS关键词	SULFONAMIDE ANTICANCER AGENT ; FACTOR CAPER-ALPHA ; PHASE-I ; SELECTIVE DEGRADATION ; RBM39 RECRUITMENT ; STRUCTURAL BASIS ; E7070 ; LENALIDOMIDE ; EXPRESSION ; BORTEZOMIB
WOS研究方向	Cell Biology
语种	英语
出版者	SPRINGERNATURE
WOS记录号	WOS:000686622600001
资助机构	National Key R&D project of the Chinese Ministry of Science and Technology ; Key Program of the National Natural Science Foundation of China ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/136602]
专题	中国科学院近代物理研究所
通讯作者	Li, Qiang; Zhang, Hong; Di, Cuixia
作者单位	1.Univ Chinese Acad Sci, Coll Life Sci, Beijing 101408, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Biomed Res Canter, Lanzhou 730000, Peoples R China 4.Adv Energy Sci & Technol Guangdong Lab, Huizhou 516029, Peoples R China 5.Med Coll Soochow, Sch Radiat Med & Protect, Suzhou 215006, Peoples R China 6.Lanzhou Univ, Sch Basic Med Sci, Lanzhou 730000, Peoples R China 7.Univ Chinese Acad Sci, Sch Nucl Sci & Technol, Beijing 101408, Peoples R China
推荐引用方式 GB/T 7714	Xu, Caipeng,Chen, Xiaohua,Zhang, Xuetian,et al. RNA-binding protein 39: a promising therapeutic target for cancer[J]. CELL DEATH DISCOVERY,2021,7(1):9.
APA	Xu, Caipeng.,Chen, Xiaohua.,Zhang, Xuetian.,Zhao, Dapeng.,Dou, Zhihui.,...&Di, Cuixia.(2021).RNA-binding protein 39: a promising therapeutic target for cancer.CELL DEATH DISCOVERY,7(1),9.
MLA	Xu, Caipeng,et al."RNA-binding protein 39: a promising therapeutic target for cancer".CELL DEATH DISCOVERY 7.1(2021):9.