In recent years, photonic crystal fibers (PCFs) have attracted increasing attention. Compared with traditional optical fibers, PCFs exhibit many unique optical properties and superior performance due to their high degree of structural design freedom. Using large-mode area (LMA) fibers with single-mode operation is essential to overcoming emerging problems as the power of fiber lasers scales up, which can effectively reduce the power density and mitigate the influence of nonlinear effects. With a brief introduction of the concept, classification, light transmission mechanism, basic properties, and theoretical analysis methods of PCFs, this paper mainly compiles the worldwide development of large-mode area and polarization-maintaining (PM) PCFs, and finally proposes possible technical routes to realize the single-mode operation of LMA-PCFs and PM-LMA-PCFs. Finally, the future development prospects of the PCFs are discussed. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.