Zinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer

doi:10.1186/s12951-021-01069-y

	Zinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer
	Pan, Xiang 4,6; Qi, Yuchen 5; Du, Zhen 3,5; He, Jian 5; Yao, Sheng 1,4; Lu, Wei 6; Ding, Kefeng 4,6; Zhou, Min 2,4,5,6
刊名	JOURNAL OF NANOBIOTECHNOLOGY
	2021-11-27
卷号	19
关键词	Zinc oxide nanoparticles Hydrogen sulfide Colorectal cancer Ferroptosis Nanoengineering Glutathione
DOI	10.1186/s12951-021-01069-y
通讯作者	Du, Zhen(duzhen90@zju.edu.cn) ; Ding, Kefeng(dingkefeng@zju.edu.cn) ; Zhou, Min(zhoum@zju.edu.cn)
英文摘要	Background: Colorectal cancer is a common malignancy occurring in the digestive system and ranks second in cancer mortality worldwide. In colorectal cancer, hydrogen sulfide (H2S) is selectively upregulated, resulting in the further exacerbation of the disease. Therefore, the clearance of H2S and the regulation of the enzymes on the H2S pathways are of great significance for colorectal cancer therapy. Methods: Here, we investigated the H2S content in various clinical tumor tissues from patients and confirmed that overproduced concentration of H2S in colorectal cancer. Accordingly, we developed an H2S-responsive nanoplatform based on zinc oxide coated virus-like silica nanoparticles (VZnO) for the therapy of colorectal cancer. Results: Owing to its excellent H2S scavenging ability, VZnO could effectively reduce H2S content in colorectal cancer to prohibit the growth of CT26 and HCT116 colorectal cancer cells. Moreover, the removal of H2S in colorectal cancer also leads to tumor inhibition through activating ferroptosis, a non-apoptotic form of cell death. The biosafety-related toxicological and pathological analysis confirmed the low toxicity and high safety of VZnO in colorectal cancer treatment. Furthermore, as an H2S-responsible nanosystem, VZnO appears to have no therapeutic effect on other non H2S rich cancers, such as the 4T1 breast cancer model. Conclusions: We anticipate that the H2S-depletion-induced ferroptosis strategy using zinc oxide-based nanomaterials would provide insights in designing nanomedicines for colorectal cancer-target theranostics and may offer clinical promise.
资助项目	National Natural Science Foundation of China[81971667] ; National Natural Science Foundation of China[32000994] ; Key Research and Development Projection of Zhejiang Province[2020C03035] ; Fundamental Research Funds for the Zhejiang Provincial Universities[2021XZZX034]
WOS关键词	GLUTATHIONE ; SYNTHASE ; ENZYME ; MOUSE ; TUMOR
WOS研究方向	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
语种	英语
出版者	BMC
WOS记录号	WOS:000723002000006
资助机构	National Natural Science Foundation of China ; Key Research and Development Projection of Zhejiang Province ; Fundamental Research Funds for the Zhejiang Provincial Universities
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/126716]
专题	中国科学院合肥物质科学研究院
通讯作者	Du, Zhen; Ding, Kefeng; Zhou, Min
作者单位	1.Zhejiang Univ, Affiliated Hosp 2, Lab Gastroenterol, Sch Med, Hangzhou 310029, Peoples R China 2.Zhejiang Univ, State Key Lab Modern Opt Instrumentat, Hangzhou 310058, Peoples R China 3.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Zhejiang Canc Hosp, Canc Hosp,Univ Chinese Acad Sci, Hangzhou 310022, Zhejiang, Peoples R China 4.Zhejiang Univ, Canc Ctr, Hangzhou 310058, Peoples R China 5.Zhejiang Univ, Inst Translat Med, Hangzhou 310029, Peoples R China 6.Zhejiang Univ, Dept Colorectal Surg & Oncol, Key Lab Canc Prevent & Intervent, Minist Educ,Affiliated Hosp 2,Sch Med, Hangzhou 310009, Peoples R China
推荐引用方式 GB/T 7714	Pan, Xiang,Qi, Yuchen,Du, Zhen,et al. Zinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer[J]. JOURNAL OF NANOBIOTECHNOLOGY,2021,19.
APA	Pan, Xiang.,Qi, Yuchen.,Du, Zhen.,He, Jian.,Yao, Sheng.,...&Zhou, Min.(2021).Zinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer.JOURNAL OF NANOBIOTECHNOLOGY,19.
MLA	Pan, Xiang,et al."Zinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer".JOURNAL OF NANOBIOTECHNOLOGY 19(2021).