The Anti-Depressive Effects of Ultra-High Static Magnetic Field

doi:10.1002/jmri.28035

	The Anti-Depressive Effects of Ultra-High Static Magnetic Field
	Lv, Yue 1,6; Fan, Yixiang 1,6; Tian, Xiaofei 4,5; Yu, Biao 1,6; Song, Chao 1,6; Feng, Chuanlin 1,6; Zhang, Lei 1,6; Ji, Xinmiao 1,6; Zablotskii, Vitalii 2,3; Zhang, Xin 1,2,4,5,6
刊名	JOURNAL OF MAGNETIC RESONANCE IMAGING
	2021-12-18
关键词	ultra-high field magnetic resonance imaging (MRI) static magnetic field (SMF) safety depression behavioral tests
ISSN号	1053-1807
DOI	10.1002/jmri.28035
通讯作者	Zhang, Xin(xinzhang@hmfl.ac.cn)
英文摘要	Background Ultra-high field magnetic resonance imaging (MRI) has obvious advantages in acquiring high-resolution images. 7 T MRI has been clinically approved and 21.1 T MRI has also been tested on rodents. Purpose To examine the effects of ultra-high field on mice behavior and neuron activity. Study Type Prospective, animal model. Animal Model Ninety-eight healthy C57BL/6 mice and 18 depression model mice. Field Strength 11.1-33.0 T SMF (static magnetic field) for 1 hour and 7 T for 8 hours. Gradients were not on and no imaging sequence was used. Assessment Open field test, elevated plus maze, three-chambered social test, Morris water maze, tail suspension test, sucrose preference test, blood routine, biochemistry examinations, enzyme-linked immunosorbent assay, immunofluorescent assay. Statistical Tests The normality of the data was assessed by Shapiro-Wilk test, followed by Student's t test or the Mann-Whitney U test for statistical significance. The statistical cut-off line is P < 0.05. Results Compared to the sham group, healthy C57/6 mice spent more time in the center area (35.12 +/- 4.034, increased by 47.19%) in open field test and improved novel index (0.6201 +/- 0.02522, increased by 16.76%) in three-chambered social test a few weeks after 1 hour 11.1-33.0 T SMF exposure. 7 T SMF exposure for 8 hours alleviated the depression state of depression mice, including less immobile time in tail suspension test (58.32% reduction) and higher sucrose preference (increased by 8.80%). Brain tissue analysis shows that 11.1-33.0 T and 7 T SMFs can increase oxytocin by 164.65% and 36.03%, respectively. Moreover, the c-Fos level in hippocampus region was increased by 14.79%. Data Conclusion 11.1-33.0 T SMFs exposure for 1 hour or 7 T SMF exposure for 8 hours did not have detrimental effects on healthy or depressed mice. Instead, these ultra-high field SMFs have anti-depressive potentials. Evidence Level 1 Technical Efficacy Stage 1
资助项目	National Natural Science Foundation of China[U21A20148] ; National Natural Science Foundation of China[52007185] ; Heye Health Technology Foundation[HYJJ20190801] ; National Science Foundation of Anhui Province[2019B365] ; China Postdoctoral Science Foundation[2019M662213] ; High Magnetic Field Laboratory of Anhui Province
WOS关键词	ANXIETY-LIKE BEHAVIOR ; C-FOS ; MRI ; NEUROGENESIS ; EXPOSURE ; SAFETY ; BRAIN
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	WILEY
WOS记录号	WOS:000731302200001
资助机构	National Natural Science Foundation of China ; Heye Health Technology Foundation ; National Science Foundation of Anhui Province ; China Postdoctoral Science Foundation ; High Magnetic Field Laboratory of Anhui Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/126434]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhang, Xin
作者单位	1.Univ Sci & Technol China, Sci Isl Branch Grad Sch, Hefei, Peoples R China 2.Int Magnetobiol Frontier Res Ctr, Hefei, Peoples R China 3.Czech Acad Sci, Inst Phys, Prague, Czech Republic 4.Anhui Univ, Inst Informat Technol, Hefei, Peoples R China 5.Anhui Univ, Inst Phys Sci, Hefei, Peoples R China 6.Chinese Acad Sci Hefei China, Key Lab High Magnet Field & Ion Beam Phys Biol, High Magnet Field Lab, Hefei Inst Phys Sci, Hefei, Peoples R China
推荐引用方式 GB/T 7714	Lv, Yue,Fan, Yixiang,Tian, Xiaofei,et al. The Anti-Depressive Effects of Ultra-High Static Magnetic Field[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2021.
APA	Lv, Yue.,Fan, Yixiang.,Tian, Xiaofei.,Yu, Biao.,Song, Chao.,...&Zhang, Xin.(2021).The Anti-Depressive Effects of Ultra-High Static Magnetic Field.JOURNAL OF MAGNETIC RESONANCE IMAGING.
MLA	Lv, Yue,et al."The Anti-Depressive Effects of Ultra-High Static Magnetic Field".JOURNAL OF MAGNETIC RESONANCE IMAGING (2021).