Prognosis of Early Stage Cervical Cancer According to Patterns of Recurrence

doi:10.2147/CMAR.S314384

	Prognosis of Early Stage Cervical Cancer According to Patterns of Recurrence
	Chen, Yuanyuan 1,3,4; Zhu, Yiming 2; Wu, Jinchang 1,3
刊名	CANCER MANAGEMENT AND RESEARCH
	2021
卷号	13
关键词	central cervical cancer pelvic prognosis recurrence
ISSN号	1179-1322
DOI	10.2147/CMAR.S314384
通讯作者	Wu, Jinchang(wjinchang@sina.com)
英文摘要	Purpose: Patterns of recurrence in cervical cancer may be useful as prognostic indicators. The aim of the present study was to determine the value of patterns of recurrence for predicting prognosis of early-stage cervical cancer. Patients and Methods: Of the 1934 patients diagnosed with primary cervical cancer between August 2008 and July 2013, 167 experienced recurrence after radical hysterectomy, including pelvic lymphadenectomy, and adjuvant postoperative treatment. The patterns of recurrence were classified into four groups: central, pelvic, distant only, and combined metastases, and the relationship between patterns of recurrence and prognosis was evaluated. Results: The patterns of lung only (21.6%), central (21.0%), and pelvic recurrence (17.4%) were the most common sites, followed by distant lymph nodes and lung with other sites. The longest 5-year survival period occurred in patients with central recurrence (70.5%), followed by distant lymph nodes (58.4%), peritoneum (58.3%), and lung only (36.8%). Late recurrence was detected in 28 patients (1.4%), who showed a better prognosis than those with early recurrence (p = 0.003). Conclusion: The patterns of recurrence help to predict prognosis. A central pattern of recurrence, distant lymph node recurrence, and peritoneal recurrence were associated with favorable outcomes after salvage therapy; however, patients who suffered other recurrent patterns, along with early recurrence, require more effective therapeutic strategies to improve survival.
资助项目	Zhejiang Medical and Health Research Project[2017KY535]
WOS关键词	RADICAL HYSTERECTOMY ; CARCINOMA ; THERAPY ; BRACHYTHERAPY ; CHEMOTHERAPY ; RADIATION ; SURGERY
WOS研究方向	Oncology
语种	英语
出版者	DOVE MEDICAL PRESS LTD
WOS记录号	WOS:000712839400001
资助机构	Zhejiang Medical and Health Research Project
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/125822]
专题	中国科学院合肥物质科学研究院
通讯作者	Wu, Jinchang
作者单位	1.Xuzhou Med Univ, Affiliated Hosp 2, Suzhou, Jiangsu, Peoples R China 2.Univ Chinese Acad Sci, Dept Gynecol Oncol, Canc Hosp, Hangzhou, Zhejiang, Peoples R China 3.Nanjing Med Univ, Dept Radiat, Affiliated Suzhou Hosp, Suzhou, Jiangsu, Peoples R China 4.Zhejiang Univ, Womens Hosp, Sch Med, Dept Radiat, Hangzhou, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Chen, Yuanyuan,Zhu, Yiming,Wu, Jinchang. Prognosis of Early Stage Cervical Cancer According to Patterns of Recurrence[J]. CANCER MANAGEMENT AND RESEARCH,2021,13.
APA	Chen, Yuanyuan,Zhu, Yiming,&Wu, Jinchang.(2021).Prognosis of Early Stage Cervical Cancer According to Patterns of Recurrence.CANCER MANAGEMENT AND RESEARCH,13.
MLA	Chen, Yuanyuan,et al."Prognosis of Early Stage Cervical Cancer According to Patterns of Recurrence".CANCER MANAGEMENT AND RESEARCH 13(2021).