Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis

doi:10.3389/fendo.2020.00265

CORC > 深海科学与工程研究所 > 中国科学院深海科学与工程研究所 > 深海科学研究部 > 深海极端环境模拟研究实验室

	Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis
	Mao, Jingxin 5,6; Zhang, Qinghai 3,6; Zhang, Haiyan 1; Zheng, Ke 2; Wang, Rui 4; Wang, Guoze 3,6
刊名	FRONTIERS IN ENDOCRINOLOGY
	2020-05-15
卷号	11 页码:12
关键词	papillary thyroid carcinoma (PTC) lymph node metastasis (LNM) risk factor prognostic factor meta-analysis
ISSN号	1664-2392
DOI	10.3389/fendo.2020.00265
英文摘要	Purpose: To explore the risk factors that may predict the lymph node metastasis potential of these lesions and new prevention strategies in papillary thyroid carcinoma patients. Materials and Methods: In total, 9,369 papillary thyroid carcinoma patients with 37.17% lymph node metastasis were analyzed (Revman 5.3 software) in this study. The PubMed and Embase databases were used for searching works systematically that were published through to January 22, 2020. Results: Several factors were related to the increased risk of lymph node metastasis in patients with papillary thyroid carcinoma: age <45 years (pooled OR = 1.52, 95% CI = 1.14-2.01, p <0.00001); gender = male (pooled OR = 1.68, 95% CI = 1.51-1.87, p <0.00001); multifocality (pooled OR = 2.05, 95% CI = 1.45-2.89, p <0.0001); tumor size >= 1.0 cm (pooled OR = 3.53, 95% CI = 2.62-4.76, p <0.00001); tumor location at the upper pole 1/3 (pooled OR =1.46, 95% CI = 1.04-2.04, p = 0.03); capsular invasion + (pooled OR = 3.48, 95% CI = 1.69-7.54, p = 0.002); and extrathyroidal extension + (pooled OR = 2.03, 95% CI= 1.78-2.31, p <0.00001). However, tumor bilaterality (pooled OR = 0.85, 95% CI = 0.54-1.34, p = 0.49) and Hashimoto's thyroditis (pooled OR = 1.08, 95% CI = 0.79-1.49, p = 0.62) showed no correlation with lymph node metastasis in papillary thyroid carcinoma patients. Conclusion: The systematic review and meta-analysis defined several significant risk factors of lymph node metastasis in papillary thyroid cancer patients: age (<45 years), gender (male), multifocality, tumor size (>1 cm), tumor location (1/3 upper), capsular invasion, and extra thyroidal extension. Bilateral tumors and Hashimoto's thyroiditis were unrelated to lymph node metastasis in patients with papillary thyroid cancer.
资助项目	first-class discipline construction project in Guizhou Province-Public Health and Preventive Medicine[2017 [85]] ; Science and Technology Support Program Project of Guizhou Province, China[2044] ; Science and Technology Support Program Project of Guizhou Province, China[2860] ; Science and Technology Support Program Project of Guizhou Province, China[2349]
WOS关键词	FINE-NEEDLE-ASPIRATION ; PREDICTIVE FACTORS ; EXTRATHYROIDAL EXTENSION ; TUMOR MULTIFOCALITY ; CANCER ; MICROCARCINOMA ; RECURRENCE ; IMPACT ; SURVEILLANCE ; DISSECTION
WOS研究方向	Endocrinology & Metabolism
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000538534800001
资助机构	first-class discipline construction project in Guizhou Province-Public Health and Preventive Medicine ; Science and Technology Support Program Project of Guizhou Province, China
内容类型	期刊论文
源URL	[http://ir.idsse.ac.cn/handle/183446/7701]
专题	深海科学研究部_深海极端环境模拟研究实验室
通讯作者	Wang, Guoze
作者单位	1.Chinese Acad Sci, Inst Deep Sea Sci & Engn, Sanya, Peoples R China 2.Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrine & Breast Surg, Chongqing, Peoples R China 3.Guizhou Med Univ, Coll Food Sci, Guiyang, Peoples R China 4.Guilin Med Univ, Coll Pharm, Dept Pharmacol, Guilin, Peoples R China 5.Southwest Univ, Coll Pharmaceut Sci, Chongqing, Peoples R China 6.Guizhou Med Univ, Minist Educ, Key Lab Environm Pollut Monitoring & Dis Control, Sch Publ Hlth, Guiyang, Peoples R China
推荐引用方式 GB/T 7714	Mao, Jingxin,Zhang, Qinghai,Zhang, Haiyan,et al. Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis[J]. FRONTIERS IN ENDOCRINOLOGY,2020,11:12.
APA	Mao, Jingxin,Zhang, Qinghai,Zhang, Haiyan,Zheng, Ke,Wang, Rui,&Wang, Guoze.(2020).Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.FRONTIERS IN ENDOCRINOLOGY,11,12.
MLA	Mao, Jingxin,et al."Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis".FRONTIERS IN ENDOCRINOLOGY 11(2020):12.