Rh(III)-Catalyzed Divergent Synthesis of Alkynylated Imidazo[1,5-a]indoles and alpha,alpha-Difluoromethylene Tetrasubstituted Alkenes

doi:10.1021/acs.orglett.1c01929

	Rh(III)-Catalyzed Divergent Synthesis of Alkynylated Imidazo[1,5-a]indoles and alpha,alpha-Difluoromethylene Tetrasubstituted Alkenes
	Zhao, Fei 1,2; Qiao, Jin 1; Lu, Yangbin 1; Zhang, Xiaoning 1; Dai, Long 1; Gong, Xin 2; Mao, Hui 5; Lu, Shiyao 1; Wu, Xiaowei 3,4; Liu, Siyu 1,2
刊名	ORGANIC LETTERS
	2021-08-06
卷号	23 期号:15 页码:5766-5771
ISSN号	1523-7060
DOI	10.1021/acs.orglett.1c01929
通讯作者	Zhao, Fei(zhaofei@cdu.edu.cn) ; Mao, Hui(maohui1988@126.com) ; Liu, Siyu(siyu.liu.siia@gmail.com)
英文摘要	Herein, we report the divergent synthesis of alkynylated imidazo[1,5-a]indoles and alpha,alpha-difluoromethylene tetrasubstituted alkenes through Rh(III)-catalyzed [4 + 1] annulation/alkyne moiety migration and C-H alkenylation/DG migration, respectively. This protocol features tunable product selectivity, excellent chemo-, regio-, and stereoselectivity, broad substrate scope, moderate to high yields, good tolerance of functional groups, and mild redox-neutral conditions.
资助项目	Natural Science Foundation of Zhejiang Province[LQ19B020003] ; Natural Science Foundation of Zhejiang Province[LY21B020003] ; National Natural Science Foundation of China[21602022] ; Chengdu Talents Program ; 1000 Talents Program of Sichuan Province ; Longquanyi District Talents Program ; Science and Technology Program of Sichuan Province[2018JY0345] ; Jinhua Branch of Sichuan Industrial Institute of Antibiotics[1003] ; Chengdu University[2081915037]
WOS关键词	INDOLES ; ALKYNES ; ANNULATION ; CLEAVAGE ; C2-ALKENYLATION ; ALKENYLATION ; DERIVATIVES ; ACTIVATION ; DESIGN ; ACIDS
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000684033200111
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/298076]
专题	中国科学院上海药物研究所
通讯作者	Zhao, Fei; Mao, Hui; Liu, Siyu
作者单位	1.Chengdu Univ, Sch Pharm, Sichuan Ind Inst Antibiot, Jinhua Branch, Jinhua 321007, Zhejiang, Peoples R China 2.Chengdu Univ, Sch Pharm, Sichuan Ind Inst Antibiot, Antibiot Res & Reevaluat Key Lab Sichuan Prov, Chengdu 610106, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Inst Drug Discovery & Dev, Zhongshan 528400, Peoples R China 5.Jinhua Polytech, Coll Pharm, Jinhua 321007, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Fei,Qiao, Jin,Lu, Yangbin,et al. Rh(III)-Catalyzed Divergent Synthesis of Alkynylated Imidazo[1,5-a]indoles and alpha,alpha-Difluoromethylene Tetrasubstituted Alkenes[J]. ORGANIC LETTERS,2021,23(15):5766-5771.
APA	Zhao, Fei.,Qiao, Jin.,Lu, Yangbin.,Zhang, Xiaoning.,Dai, Long.,...&Liu, Siyu.(2021).Rh(III)-Catalyzed Divergent Synthesis of Alkynylated Imidazo[1,5-a]indoles and alpha,alpha-Difluoromethylene Tetrasubstituted Alkenes.ORGANIC LETTERS,23(15),5766-5771.
MLA	Zhao, Fei,et al."Rh(III)-Catalyzed Divergent Synthesis of Alkynylated Imidazo[1,5-a]indoles and alpha,alpha-Difluoromethylene Tetrasubstituted Alkenes".ORGANIC LETTERS 23.15(2021):5766-5771.