New formamidobisabolene-type sesquiterpenoids from a Hainan Sponge Halichondria sp. | |
Chen, Bao1,2; Li, Wang-Sheng1,5; Gu, Yu-Cheng6; Zhang, Hai-Yan4; Luo, Hui5; Wang, Chang-Yun2,3; Guo, Yue-Wei1,3; Li, Xu-Wen1,3 | |
刊名 | TETRAHEDRON |
2021-09-10 | |
卷号 | 96页码:7 |
关键词 | Sponge Halichondria sp Anti-inflammatory activity Sesquiterpenes |
ISSN号 | 0040-4020 |
DOI | 10.1016/j.tet.2021.132396 |
通讯作者 | Wang, Chang-Yun(changyun@ouc.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn) ; Li, Xu-Wen(xwli@simm.ac.cn) |
英文摘要 | Chemical study of a Hainan sponge Halichondria sp. resulted in the isolation of eight new formamidobisabolene-based sesquiterpenes halichines A-E (1-3, 7, 8), ent-axinyssine G [(-)-4], entaxinyssine J [(-)-5], and ent-axinyssine K [(-)-6], along with five related known ones [(+)-4, (+)-5, (+)-6, 10, 11]. Their structures were determined on the basis of extensive spectroscopic analyses, and the absolute configuration of halichine A (1) was determined by Snatzke's method. In bioassay, compounds 3 and 7 displayed considerable anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated BV-2 microglia cells. (c) 2021 Elsevier Ltd. All rights reserved. |
资助项目 | National Natural Science Foundation of China[82022069] ; National Natural Science Foundation of China[81991521] ; National Natural Science Foundation of China[42076099] ; National Natural Science Foundation of China[41830535] ; Shanghai Rising-Star Program[20QA1411100] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[Y202065] ; SKLDR/SIMM Project[SIMM2103ZZ-06] ; Taishan Scholars Program, China ; Syngenta-OUC-PhD Studentship Project |
WOS关键词 | BISABOLENE-TYPE SESQUITERPENES ; MARINE SPONGE |
WOS研究方向 | Chemistry |
语种 | 英语 |
出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
WOS记录号 | WOS:000690877000017 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/297693] |
专题 | 中国科学院上海药物研究所 |
通讯作者 | Wang, Chang-Yun; Guo, Yue-Wei; Li, Xu-Wen |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 2.Ocean Univ China, Sch Med & Pharm, Minist Educ China, China Key Lab Marine Drugs, Qingdao 266003, Peoples R China 3.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 5.Guangdong Med Univ, Marine Biomed Res Inst, Key Lab Zhanjiang R&D Marine Microbial Resources, Zhanjiang 524023, Peoples R China 6.Jealotts Hill Int Res Ctr, Syngenta, Bracknell RG42 6EY, Berks, England |
推荐引用方式 GB/T 7714 | Chen, Bao,Li, Wang-Sheng,Gu, Yu-Cheng,et al. New formamidobisabolene-type sesquiterpenoids from a Hainan Sponge Halichondria sp.[J]. TETRAHEDRON,2021,96:7. |
APA | Chen, Bao.,Li, Wang-Sheng.,Gu, Yu-Cheng.,Zhang, Hai-Yan.,Luo, Hui.,...&Li, Xu-Wen.(2021).New formamidobisabolene-type sesquiterpenoids from a Hainan Sponge Halichondria sp..TETRAHEDRON,96,7. |
MLA | Chen, Bao,et al."New formamidobisabolene-type sesquiterpenoids from a Hainan Sponge Halichondria sp.".TETRAHEDRON 96(2021):7. |
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