Functionalized nanoporous gold membrane for pancreatic islet cells encapsulation

doi:10.1016/j.matlet.2021.130224

CORC > 金属研究所 > 中国科学院金属研究所

	Functionalized nanoporous gold membrane for pancreatic islet cells encapsulation
	Chen, Shi-ting 2; He, Si-yuan 2; Wang, Wan-ying 3; Jin, Hai-jun 1; Lu, Jian 4; Zhang, Ye-yuan 1
刊名	MATERIALS LETTERS
	2021-10-15
卷号	301 页码:3
关键词	Nanoporous gold Dealloying Cell encapsulation Diabetes treatment Biomaterials Porous material
ISSN号	0167-577X
DOI	10.1016/j.matlet.2021.130224
通讯作者	He, Si-yuan(hesiyuan@gmail.com)
英文摘要	Nanoporous gold (NPG) is promising to functionalize as an immunoisolation membrane in cell encapsulation therapy (CET) due to its tunable pore structure. Herein, we evaluated the potential utilization of NPG membrane for the encapsulation of pancreatic islet cells, that is, a practical CET to correct the diabetic state. The results showed that the NPG membrane maintained the viability of mouse insulinoma 6 (MIN6) cells and allowed the sufficient exchange of substances for cell metabolism over 4 days. In vitro, the glucose-stimulated insulin released by encapsulated cells was detected, demonstrating the functional performance of the NPG-encapsulation.
资助项目	National Natural ScienceFoundation of China[52071057] ; National Natural ScienceFoundation of China[11572087]
WOS研究方向	Materials Science ; Physics
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000675889300005
资助机构	National Natural ScienceFoundation of China
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/159812]
专题	金属研究所_中国科学院金属研究所
通讯作者	He, Si-yuan
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China 2.Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Jiangsu Key Lab Biomat & Devices, Nanjing 210096, Peoples R China 3.City Univ Hong Kong, Dept Biomed Sci, Hong Kong, Peoples R China 4.City Univ Hong Kong, Dept Mech Engn, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Chen, Shi-ting,He, Si-yuan,Wang, Wan-ying,et al. Functionalized nanoporous gold membrane for pancreatic islet cells encapsulation[J]. MATERIALS LETTERS,2021,301:3.
APA	Chen, Shi-ting,He, Si-yuan,Wang, Wan-ying,Jin, Hai-jun,Lu, Jian,&Zhang, Ye-yuan.(2021).Functionalized nanoporous gold membrane for pancreatic islet cells encapsulation.MATERIALS LETTERS,301,3.
MLA	Chen, Shi-ting,et al."Functionalized nanoporous gold membrane for pancreatic islet cells encapsulation".MATERIALS LETTERS 301(2021):3.