RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function
	Shi, Boyang; Zhang, Jinsong; Heng, Jian; Gong, Jing; Zhang, Ting; Li, Pan; Sun, Bao-Fa; Yang, Ying; Zhang, Ning; Zhao, Yong-Liang
刊名	GENOME BIOLOGY
	2020-05-18
卷号	21 期号:1 页码:1-2
关键词	RNA structure Zebrafish early embryogenesis Structure-based regulome Elavl1a
ISSN号	1474-760X
英文摘要	Background Vertebrate early embryogenesis is initially directed by a set of maternal RNAs and proteins, yet the mechanisms controlling this program remain largely unknown. Recent transcriptome-wide studies on RNA structure have revealed its pervasive and crucial roles in RNA processing and functions, but whether and how RNA structure regulates the fate of the maternal transcriptome have yet to be determined. Results Here we establish the global map of four nucleotide-based mRNA structures by icSHAPE during zebrafish early embryogenesis. Strikingly, we observe that RNA structurally variable regions are enriched in the 3 ' UTR and contain cis-regulatory elements important for maternal-to-zygotic transition (MZT). We find that the RNA-binding protein Elavl1a stabilizes maternal mRNAs by binding to the cis-elements. Conversely, RNA structure formation suppresses Elavl1a's binding leading to the decay of its maternal targets. Conclusions Our study finds that RNA structurally variable regions are enriched in mRNA 3 ' UTRs and contain cis-regulatory elements during zebrafish early embryogenesis. We reveal that Elavl1a regulates maternal RNA stability in an RNA structure-dependent fashion. Overall, our findings reveal a broad and fundamental role of RNA structure-based regulation in vertebrate early embryogenesis.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/44799]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Shi, Boyang,Zhang, Jinsong,Heng, Jian,et al. RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function[J]. GENOME BIOLOGY,2020,21(1):1-2.
APA	Shi, Boyang.,Zhang, Jinsong.,Heng, Jian.,Gong, Jing.,Zhang, Ting.,...&Yang, Yun-Gui.(2020).RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function.GENOME BIOLOGY,21(1),1-2.
MLA	Shi, Boyang,et al."RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function".GENOME BIOLOGY 21.1(2020):1-2.