Probing the role of mesenchymal stem cells in salivary gland cancer on biomimetic microdevices

	Probing the role of mesenchymal stem cells in salivary gland cancer on biomimetic microdevices
	Ma, Huipeng; Zhang, Min; Qin, Jianhua
刊名	integrative biology
	2012
卷号	4 期号:5 页码:522-530
通讯作者	秦建华
产权排序	1,1
英文摘要	mesenchymal stem cells (mscs) are the progenitors of stromal cells, which have been found to interact with cancer cells and represent an important target for cancer therapies. salivary gland cancer is an aggressive malignant epithelial tumor and can easily disseminate to distant sites in vivo. in this work, we probed the role of mscs in salivary gland cancer in an in vivo like tumor microenvironment by using a series of functional microfluidic devices for 2d and 3d assays. the results demonstrated that mscs could be recruited by salivary gland cancer cells (acc-m) and this effect was potentially mediated by tgf-beta secreted by cancer cells. in addition, mscs exhibited the ability to squeeze into acc-m spheroids by dispersing the cell-cell connection and reducing the expression of e-cadherin in cancer cells. in particular, mscs exhibited the ability to enhance the invasion of salivary cancer under a chemokine cxcl12 gradient, indicating the involvement of a cxcl12-cxcr4 pathway and the tumor-promoting properties of mscs in cancer progression. this study recreated an in vivo-like tumor microenvironment by constructing a series of functional microdevices and explored the role of mscs in acc invasion for the first time. it provides a unique platform to open up new options to target stromal cells for cancer therapy and also analyzed the potential risk of using mscs as drug delivery carriers for therapeutic purposes in carcinoma treatment.
学科主题	物理化学
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	cell biology
研究领域[WOS]	cell biology
关键词[WOS]	adenoid cystic carcinoma ; marrow stromal cells ; tumor-cells ; fibroblasts ; cxcr4 ; metastasis ; growth ; lung ; therapies ; melanoma
收录类别	SCI
语种	英语
WOS记录号	WOS:000303321100007
公开日期	2013-10-11
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/117875]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Beijing 100864, Peoples R China
推荐引用方式 GB/T 7714	Ma, Huipeng,Zhang, Min,Qin, Jianhua. Probing the role of mesenchymal stem cells in salivary gland cancer on biomimetic microdevices[J]. integrative biology,2012,4(5):522-530.
APA	Ma, Huipeng,Zhang, Min,&Qin, Jianhua.(2012).Probing the role of mesenchymal stem cells in salivary gland cancer on biomimetic microdevices.integrative biology,4(5),522-530.
MLA	Ma, Huipeng,et al."Probing the role of mesenchymal stem cells in salivary gland cancer on biomimetic microdevices".integrative biology 4.5(2012):522-530.