Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China | |
Ke Deng16; Ji-Hui Yue15; Jian Xu14; Ping-Ping Ma14,15; Xiao Chen12,13; Le Li12,13; Tong-Jian Bai 6 , Qi-Jing Bo11; Qi-Jing Bo10; Jun Cao9; Guan-Mao Chen8 | |
刊名 | Bipolar disorders |
2021 | |
通讯作者邮箱 | yuqicheng@126.com (yuqi cheng) |
DOI | 10.1111/BDI.13139 |
英文摘要 | Background: Recently, functional homotopy (FH) architecture, defined as robust functional connectivity (FC) between homotopic regions, has been frequently reported to be altered in MDD patients (MDDs) but with divergent locations. Methods: In this study, we obtained resting-state functional magnetic resonance imaging (R-fMRI) data from 1004 MDDs (mean age, 33.88 years; age range, 18-60 years) and 898 matched healthy controls (HCs) from an aggregated dataset from 20 centers in China. We focused on interhemispheric function integration in MDDs and its correlation with clinical characteristics using voxel-mirrored homotopic connectivity (VMHC) devised to inquire about FH patterns. Results: As compared with HCs, MDDs showed decreased VMHC in visual, motor, somatosensory, limbic, angular gyrus, and cerebellum, particularly in posterior cingulate gyrus/precuneus (PCC/PCu) (false discovery rate [FDR] q < .002, z =-7.07). Further analysis observed that the reduction in SMG and insula was more prominent with age, of which SMG reflected such age-related change in males instead of females. Besides, the reduction of MTG was found to be a male-special abnormal pattern in MDDs. VMHC alterations were markedly related to episode type and illness severity. The higher Hamilton Depression Rating Scale score, the more apparent VMHC reduction in the primary visual cortex. First-episode MDDs revealed stronger VMHC reduction in PCu relative to recurrent MDDs. Conclusions: We confirmed a significant VMHC reduction in MDDs in broad areas, especially in PCC/PCu. This reduction was affected by gender, age, episode type, and illness severity. These findings suggest that the depressive brain tends to disconnect information exchange across hemispheres. |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/40719] |
专题 | 心理研究所_中国科学院行为科学重点实验室 |
作者单位 | 1.Department of Psychiatry, Sir Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China 2.Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210096, China 3.Psychoradiology Research Unit of Chinese Academy of Medical Sciences, West China Hospital of Sichuan 4.Department of Radiology, Huaxi MR Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China 5.Department of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China 6.Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, China 7.Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China 8.The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China 9.Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China 10.Beijing Anding Hospital, Capital Medical University, Beijing 100054, China |
推荐引用方式 GB/T 7714 | Ke Deng,Ji-Hui Yue,Jian Xu,et al. Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China[J]. Bipolar disorders,2021. |
APA | Ke Deng.,Ji-Hui Yue.,Jian Xu.,Ping-Ping Ma.,Xiao Chen.,...&Zheng-Hua Hou.(2021).Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China.Bipolar disorders. |
MLA | Ke Deng,et al."Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China".Bipolar disorders (2021). |
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