Autoantibody against the Rab6A/Rab6B in primary autoimmune cerebellar ataxia associated with Sjogren's syndrome: A case report

doi:10.1016/j.jneuroim.2021.577667

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	Autoantibody against the Rab6A/Rab6B in primary autoimmune cerebellar ataxia associated with Sjogren's syndrome: A case report
	Guo, Liyuan 2,3; Ren, Haitao 1; Fan, Siyuan 1; Guan, Hongzhi 1; Wang, Jing 2,3
刊名	JOURNAL OF NEUROIMMUNOLOGY
	2021-10-15
通讯作者邮箱	guanhz@263.net (h. guan) ; wangjing@psych.ac.cn (j. wang)
卷号	359 页码:7
关键词	Autoimmune Cerebellar ataxia Novel autoantibody Anti-Rab6A Rab6B antibody
ISSN号	0165-5728
DOI	10.1016/j.jneuroim.2021.577667
产权排序	1
文献子类	评论
英文摘要	In the current study we report a novel autoantibody against Purkinje cells in a patient with primary autoimmune cerebellar ataxia (PACA) associated with Sjogren's syndrome (SS). Tissue-based indirect immunofluorescence assay (TBA) of the patient's serum and cerebrospinal fluid (CSF) revealed IgG antibody to Purkinje cells and the granular layer of the rat cerebellum. Rab6A was identified as autoantigen by mass spectrometry (MS) and Western blotting, and the interactions between Rab6A or its homologous Rab6B and autoantibody in patient serum were verified by recombinant cell-based assay (CBA) and neutralization experiments. This autoantibody may represent a novel biomarker in the diagnosis of PACA.
收录类别	SCI
资助项目	National Key Research and Develop-ment Program of China[2016YFC0901500] ; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
WOS关键词	MUTATIONS ; DISEASE ; WEAKNESS
WOS研究方向	Immunology ; Neurosciences & Neurology
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000695211500008
资助机构	National Key Research and Develop-ment Program of China ; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/40234]
专题	心理研究所_中国科学院心理健康重点实验室
通讯作者	Guan, Hongzhi; Wang, Jing
作者单位	1.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurol, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Guo, Liyuan,Ren, Haitao,Fan, Siyuan,et al. Autoantibody against the Rab6A/Rab6B in primary autoimmune cerebellar ataxia associated with Sjogren's syndrome: A case report[J]. JOURNAL OF NEUROIMMUNOLOGY,2021,359:7.
APA	Guo, Liyuan,Ren, Haitao,Fan, Siyuan,Guan, Hongzhi,&Wang, Jing.(2021).Autoantibody against the Rab6A/Rab6B in primary autoimmune cerebellar ataxia associated with Sjogren's syndrome: A case report.JOURNAL OF NEUROIMMUNOLOGY,359,7.
MLA	Guo, Liyuan,et al."Autoantibody against the Rab6A/Rab6B in primary autoimmune cerebellar ataxia associated with Sjogren's syndrome: A case report".JOURNAL OF NEUROIMMUNOLOGY 359(2021):7.