Robust hemostatic bandages based on nanoclay electrospun membranes

doi:10.1038/s41467-021-26237-4

	Robust hemostatic bandages based on nanoclay electrospun membranes
	Cui, Yan 1,2; Huang, Zongwang 1; Lei, Li 3; Li, Qinglin 4,5; Jiang, Jinlong 6; Zeng, Qinghai 3; Tang, Aidong 2; Yang, Huaming 1; Zhang, Yi 1
刊名	NATURE COMMUNICATIONS
	2021-10-11
卷号	12
DOI	10.1038/s41467-021-26237-4
通讯作者	Zhang, Yi(yee_z10@csu.edu.cn)
英文摘要	Rapid, easy and effective haemostasis is needed to reduce the loss of life from traumatic haemorrhage. Here, the authors report on the creation of polymer-nanoclay electrospun membranes and demonstrate haemostatic effects showing superior effects to other clay based haemostats. Death from acute hemorrhage is a major problem in military conflicts, traffic accidents, and surgical procedures, et al. Achieving rapid effective hemostasis for pre-hospital care is essential to save lives in massive bleeding. An ideal hemostasis material should have those features such as safe, efficient, convenient, economical, which remains challenging and most of them cannot be achieved at the same time. In this work, we report a rapid effective nanoclay-based hemostatic membranes with nanoclay particles incorporate into polyvinylpyrrolidone (PVP) electrospun fibers. The nanoclay electrospun membrane (NEM) with 60 wt% kaolinite (KEM1.5) shows better and faster hemostatic performance in vitro and in vivo with good biocompatibility compared with most other NEMs and clay-based hemostats, benefiting from its enriched hemostatic functional sites, robust fluffy framework, and hydrophilic surface. The robust hemostatic bandages based on nanoclay electrospun membrane is an effective candidate hemostat in practical application.
资助项目	NSFC[21878341] ; NSFC[51804343] ; Strategic Priority Research Program of Central South University[ZLXD2017005] ; Natural Science Foundation of Hunan Province[2018JJ3670] ; Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hosipital of Central South University[YX202007] ; Foundation of Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province[HPK201703]
WOS关键词	HALLOYSITE CLAY NANOTUBES ; COMPOSITE SPONGE ; FABRICATION ; HEMORRHAGE ; RELEASE ; SILICA ; SCALE
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PORTFOLIO
WOS记录号	WOS:000706146500013
资助机构	NSFC ; Strategic Priority Research Program of Central South University ; Natural Science Foundation of Hunan Province ; Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hosipital of Central South University ; Foundation of Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/125627]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhang, Yi
作者单位	1.Cent South Univ, Sch Minerals Proc & Bioengn, Dept Inorgan Mat, Changsha 410083, Peoples R China 2.Cent South Univ, Coll Chem & Chem Engn, Changsha 410083, Peoples R China 3.Cent South Univ, Xiangya Hosp 2, Dept Dermatol, Changsha 410013, Peoples R China 4.Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp, Hangzhou, Peoples R China 5.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou, Peoples R China 6.Huaiyin Inst Technol, Jiangsu Prov Key Lab Palygorskite Sci & Appl Tech, Huaian 223003, Peoples R China
推荐引用方式 GB/T 7714	Cui, Yan,Huang, Zongwang,Lei, Li,et al. Robust hemostatic bandages based on nanoclay electrospun membranes[J]. NATURE COMMUNICATIONS,2021,12.
APA	Cui, Yan.,Huang, Zongwang.,Lei, Li.,Li, Qinglin.,Jiang, Jinlong.,...&Zhang, Yi.(2021).Robust hemostatic bandages based on nanoclay electrospun membranes.NATURE COMMUNICATIONS,12.
MLA	Cui, Yan,et al."Robust hemostatic bandages based on nanoclay electrospun membranes".NATURE COMMUNICATIONS 12(2021).