Plasma-activated thermosensitive biogel as an exogenous ROS carrier for post-surgical treatment of cancer

doi:10.1016/j.biomaterials.2021.121057

	Plasma-activated thermosensitive biogel as an exogenous ROS carrier for post-surgical treatment of cancer
	Zhang, Hao 1; Xu, Shengduo 1; Zhang, Jishen 1; Wang, Zifeng 1; Liu, Dingxin 1; Guo, Li 1; Cheng, Cheng 2,3,4; Cheng, Yilong 5; Xu, Dehui 1; Kong, Michael G.1,6
刊名	BIOMATERIALS
	2021-09-01
卷号	276
关键词	Post-operative tumor treatment Surface discharge plasma Reactive oxygen species Plasma-activated biogel
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2021.121057
通讯作者	Liu, Dingxin(liudingxin@mail.xjtu.edu.cn)
英文摘要	Post-surgical residual tumor cells are the primary cause of relapse and progression of cancer but unfortunately, there are limited therapeutic options. In this work, a fillable plasma-activated biogel is produced on a thermosensitive biogel [(Poly-DL-lactide)-(poly-ethylene glycol)-(poly-DL-lactide), PLEL] with the aid of a discharge plasma for local post-operative treatment of cancer. In vivo data show that the plasma-activated PLEL biogel (PAPB) eliminates residual tumor tissues after removal surgery and also inhibits in situ recurrence while showing no evident systemic toxicity. Moreover, the PAPB possesses excellent storage capability, allows for slow release of plasma-generated reactive oxygen species (ROS), and exhibits good ROS-mediated anticancer effects in vitro. Our results reveal that the novel plasma-activated biogel is an effective therapeutic agent for local post-operative treatment of cancer.
资助项目	National Natural Science Foundation of China[51907158] ; National Natural Science Foundation of China[51677147] ; National Natural Science Foundation of China[51837008] ; City University of Hong Kong Strategic Research Grant (SRG)[7005264]
WOS关键词	ADJUVANT CHEMOTHERAPY ; COLD-PLASMA ; DNA-DAMAGE ; CELL-DEATH ; SURGERY ; HEAD
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000690437900002
资助机构	National Natural Science Foundation of China ; City University of Hong Kong Strategic Research Grant (SRG)
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/125110]
专题	中国科学院合肥物质科学研究院
通讯作者	Liu, Dingxin
作者单位	1.Xi An Jiao Tong Univ, Ctr Plasma Biomed, State Key Lab Elect Insulat & Power Equipment, Xian 710049, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Plasma Phys, POB 1126, Hefei 230031, Anhui, Peoples R China 3.City Univ Hong Kong, Dept Mat Sci & Engn, Dept Phys, Kowloon, Tat Chee Ave, Hong Kong, Peoples R China 4.City Univ Hong Kong, Dept Biomed Engn, Tat Chee Ave, Hong Kong, Peoples R China 5.Xi An Jiao Tong Univ, Sch Sci, Dept Appl Phys, Xian 710049, Shaanxi, Peoples R China 6.Old Dominion Univ, Dept Elect & Comp Engn, Norfolk, VA 23529 USA
推荐引用方式 GB/T 7714	Zhang, Hao,Xu, Shengduo,Zhang, Jishen,et al. Plasma-activated thermosensitive biogel as an exogenous ROS carrier for post-surgical treatment of cancer[J]. BIOMATERIALS,2021,276.
APA	Zhang, Hao.,Xu, Shengduo.,Zhang, Jishen.,Wang, Zifeng.,Liu, Dingxin.,...&Chu, Paul K..(2021).Plasma-activated thermosensitive biogel as an exogenous ROS carrier for post-surgical treatment of cancer.BIOMATERIALS,276.
MLA	Zhang, Hao,et al."Plasma-activated thermosensitive biogel as an exogenous ROS carrier for post-surgical treatment of cancer".BIOMATERIALS 276(2021).