Terahertz detection of porosity and porous microstructure in pharmaceutical tablets: A review

doi:10.1016/j.ijpharm.2020.120006

	Terahertz detection of porosity and porous microstructure in pharmaceutical tablets: A review
	Lu, Xingxing 2; Sun, Huihui 2; Chang, Tianying 2,3; Zhang, Jin 2; Cui, Hong-Liang 1,2
刊名	INTERNATIONAL JOURNAL OF PHARMACEUTICS
	2020-12-15
卷号	591 页码:10
关键词	Pharmaceutical tablets THz technology Porosity Porous microstructure
ISSN号	0378-5173
DOI	10.1016/j.ijpharm.2020.120006
通讯作者	Zhang, Jin()
英文摘要	Pores are inevitably produced during the production of pharmaceutical tablets, which greatly affects a range of tablet properties such as hardness, friability, tensile strength, disintegration, dissolution, and ultimately the bioavailability of an orally administered tablet. The pursuit of speed and non-destructiveness in detection of pores in pharmaceutical tablets has recently ushered in the use of terahertz (THz) techniques. This review briefly introduces the mechanism of the formation of the pores in tablets and the traditional methods of detecting them. The main focus is the relevant research work of THz technology applied to the detection of the pores in tablets, including the quantitative detection of porosity and analysis of porous microstructure. It also discusses the challenges and the future development directions of THz technology in the detection of pores in tablets.
资助项目	National Natural Science Foundation of China[61705120] ; National Natural Science Foundation of China[61875196]
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000600735200039
内容类型	期刊论文
源URL	[http://119.78.100.138/handle/2HOD01W0/12688]
专题	中国科学院重庆绿色智能技术研究院
通讯作者	Zhang, Jin
作者单位	1.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China 2.Jilin Univ, Coll Instrumentat & Elect Engn, Changchun 130061, Jilin, Peoples R China 3.Qilu Univ Technol, Inst Automat, Shandong Acad Sci, Jinan 250014, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Lu, Xingxing,Sun, Huihui,Chang, Tianying,et al. Terahertz detection of porosity and porous microstructure in pharmaceutical tablets: A review[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2020,591:10.
APA	Lu, Xingxing,Sun, Huihui,Chang, Tianying,Zhang, Jin,&Cui, Hong-Liang.(2020).Terahertz detection of porosity and porous microstructure in pharmaceutical tablets: A review.INTERNATIONAL JOURNAL OF PHARMACEUTICS,591,10.
MLA	Lu, Xingxing,et al."Terahertz detection of porosity and porous microstructure in pharmaceutical tablets: A review".INTERNATIONAL JOURNAL OF PHARMACEUTICS 591(2020):10.