Prioritizing selected PPCPs on the basis of environmental and toxicogenetic concerns: A toxicity estimation to confirmation approach

doi:10.1016/j.jhazmat.2019.120828

	Prioritizing selected PPCPs on the basis of environmental and toxicogenetic concerns: A toxicity estimation to confirmation approach
	Junaid, Muhammad 1,2,3; Wang, Yan 1,2; Hamid, Naima 1,2; Deng, Shun 2; Li, Wei-Guo 3; Pei, De-Sheng 1,2,3
刊名	JOURNAL OF HAZARDOUS MATERIALS
	2019-12-15
卷号	380 页码:12
关键词	Developmental toxicity Zebrafish HEK293T cells Detoxification Ecological risks
ISSN号	0304-3894
DOI	10.1016/j.jhazmat.2019.120828
通讯作者	Pei, De-Sheng(peids@cigit.ac.cn)
英文摘要	Pharmaceuticals and personal care products (PPCPs), the pollutants of emerging concerns, present potential risks to the ecological environment. This study focused on the prioritization of widely used selected PPCPs belonging to two categories:personal care products (PCPs) and non-steroidal anti-inflammatory drugs (NSAIDs). We predicted the toxicogenetic endpoints of PPCPs and then confirmed them using experimental approaches. Our results revealed a significant similarity in the findings obtained through both approaches, indicating NSAIDs with relatively high environmental impacts and in vitro/vivo toxicity. Experimental approach revealed that musk xylene (MX) from PCPs and DIC from NSAIDs as individual chemicals of priority concern showed elevated environmental impacts and significantly induced pi3k-akt-mTOR in vitro. Similarly, propyl paraben (PP) from PCPs and diclofenac (DIC) from NSAIDs caused significant cytotoxicity and DNA damage in vitro. Moreover, PP and MX from the PCPs group and naproxen (NAP) and DIC from the NSAIDs group induced developmental toxicity and perturbations to phases I, II, and III detoxification pathways in vivo. In addition, MX and DIC as priority PPCPs inhibited hematopoiesis and hepatogenesis in vivo. Apart from the specific effects, PPCPs can be ranked as: MX > PP > methylparaben (MP) for PCPs, and DIC > NAP > ibuprofen (IBU) for NSAIDs, regarding their toxic and environmental concerns.
资助项目	CAS Team Project of the Belt and Road ; Three Hundred Leading Talents in Scientific and Technological Innovation Program of Chongqing[CSTCCXLJRC201714] ; Program of China-Sri Lanka Joint Research and Demonstration Center for Water Technology by Chinese Academy of Sciences, China ; China-Sri Lanka Joint Center for Education and Research by Chinese Academy of Sciences, China
WOS研究方向	Engineering ; Environmental Sciences & Ecology
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000491683300012
内容类型	期刊论文
源URL	[http://119.78.100.138/handle/2HOD01W0/10316]
专题	中国科学院重庆绿色智能技术研究院
通讯作者	Pei, De-Sheng
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Key Lab Reservoir Aquat Environm, Chongqing 400714, Peoples R China 3.Henan Normal Univ, Coll Life Sci, Xinxiang 453007, Henan, Peoples R China
推荐引用方式 GB/T 7714	Junaid, Muhammad,Wang, Yan,Hamid, Naima,et al. Prioritizing selected PPCPs on the basis of environmental and toxicogenetic concerns: A toxicity estimation to confirmation approach[J]. JOURNAL OF HAZARDOUS MATERIALS,2019,380:12.
APA	Junaid, Muhammad,Wang, Yan,Hamid, Naima,Deng, Shun,Li, Wei-Guo,&Pei, De-Sheng.(2019).Prioritizing selected PPCPs on the basis of environmental and toxicogenetic concerns: A toxicity estimation to confirmation approach.JOURNAL OF HAZARDOUS MATERIALS,380,12.
MLA	Junaid, Muhammad,et al."Prioritizing selected PPCPs on the basis of environmental and toxicogenetic concerns: A toxicity estimation to confirmation approach".JOURNAL OF HAZARDOUS MATERIALS 380(2019):12.