Three new indole alkaloid glycosides with unusual structural features from the roots of Isatis indigotica

doi:10.1016/j.phytol.2020.08.005

	Three new indole alkaloid glycosides with unusual structural features from the roots of Isatis indigotica
	Zhang, Dongdong 1; Sun, Yu 1; Ruan, Deqing 2; Li, Jingyi 2; Chen, Kaixian 2,3; Li, Yiming 2; Wang, Rui 2
刊名	PHYTOCHEMISTRY LETTERS
	2020-10-01
卷号	39 页码:168-172
关键词	Isatis indigotica root Indole alkaloid glycosides Anti-inflammatory activity Isatindigosides K and L
ISSN号	1874-3900
DOI	10.1016/j.phytol.2020.08.005
通讯作者	Wang, Rui(wr@shutcm.edu.cn)
英文摘要	Three new indole alkaloid glycosides were obtained from the roots of Isatis indigotica (I. indigotica). Compounds 1a and 1b were determined to be a pair of epimers with an unusual 1-[6-(1H-indole-3-yl)-2H-1,2,4-thiadiazin-3-yl]but-3-en-2-ol skeleton by chiral-phase chromatography and electronic circular dichroism (ECD) data analysis and their putative biosynthetic pathways were proposed. Compound 2 possesses an uncommon 5-(1H-indol-3-yl) pyrrolidin-2-one skeleton. Their nitric oxide (NO) inhibitory effects were tested in LPS-stimulated RAW 264.7 cells, however, none of them exhibited inhibitory activities.
资助项目	National Natural Science Foundation of China[81573571] ; National Natural Science Foundation of China[81673570] ; Excellent Academic Leaders Program of Shanghai[16XD1403500] ; programs of High Level University Innovation Team, Shanghai E-Research Institute of Bioactive Constituents in Traditional Chinese Medicine ; Shanghai Scientific and Technological Innovation Program[18401931100]
WOS关键词	AQUEOUS EXTRACT ; DERIVATIVES ; GLUCOSIDES
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000585754900030
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296450]
专题	中国科学院上海药物研究所
通讯作者	Wang, Rui
作者单位	1.Shaanxi Univ Chinese Med, Sch Pharm, Xianyang 712046, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Dongdong,Sun, Yu,Ruan, Deqing,et al. Three new indole alkaloid glycosides with unusual structural features from the roots of Isatis indigotica[J]. PHYTOCHEMISTRY LETTERS,2020,39:168-172.
APA	Zhang, Dongdong.,Sun, Yu.,Ruan, Deqing.,Li, Jingyi.,Chen, Kaixian.,...&Wang, Rui.(2020).Three new indole alkaloid glycosides with unusual structural features from the roots of Isatis indigotica.PHYTOCHEMISTRY LETTERS,39,168-172.
MLA	Zhang, Dongdong,et al."Three new indole alkaloid glycosides with unusual structural features from the roots of Isatis indigotica".PHYTOCHEMISTRY LETTERS 39(2020):168-172.